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Pancreatic Duct Obstruction in the Pig: Electron Microscopy of Chronic Pancreatitis

Obstruktion av ductus pancreaticus hos svin. En elektronmikroskopisk undersökning av kronisk pankreatit

Acta Veterinaria Scandinavica volume 29, pages 255–258 (1988)Cite this article

Abstract

Ultrastructural alterations of pancreatic tissues in growing pigs caused by surgical ligation of the main pancreatic duct are described. Five animals aged 6 to 7 weeks were operated on and necropsied 2, 6 or 8 weeks later. In addition, 3 pigs that were sham-operated served as controls. Obstruction of the ducts caused progressive luminal dilatations and rupture of intercellular connections of the epithelium followed by destruction and atrophy of acinar parenchyma and proliferations of immature ductular epithelial cells free from zymogen granules.

Sammanfattning

Morfologiska alterationer i pankreasvävnaden beskrivs hos växande svin med ligerad pankreasgång. Fem försöksdjur, 6–7 veckor gamla, opererades och obducerades 2, 6 och 8 veckor senare. Som kontroll användes 3 sham-opererade svin. Obstruktionen förorsakade progressiv dilatation av den ligerade pankreasgången och intercellulära rupturer i epitelet. Den akinära vävnaden atrofierades och ersattes med proliferationer av immatura epitelceller utan zymogengranula.

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Acknowledgements

Electron microscopial studies were performed in the Laboratory of Electron Microscopy, College of Veterinary Medicine, Helsinki.

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Authors and Affiliations

  1. The Department of Pathology and Livestock Hygiene, College of Veterinary Medicine and The Second Department of Surgery, University of Helsinki, PL 6, SF-00551, Helsinki, Finland

    Timo Rahko, Hannu Saloniemi & Timo V. Kalima

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  1. Timo Rahko
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  2. Hannu Saloniemi
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  3. Timo V. Kalima
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Rahko, T., Saloniemi, H. & Kalima, T.V. Pancreatic Duct Obstruction in the Pig: Electron Microscopy of Chronic Pancreatitis. Acta Vet Scand 29, 255–258 (1988). https://doi.org/10.1186/BF03548379

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Acta Veterinaria Scandinavica

ISSN: 1751-0147