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Clinical and Endocrine Response to Repeated Daily Administration of Endotoxin in Pigs

Acta Veterinaria Scandinavica volume 29, pages 267–269 (1988)Cite this article

Abstract

Endotoxins of Gram-negative bacteria elicit biphasic fever, leukopenia, increased hypocalcemia, PGF2α release, and blood-circulation shock in the mammalian body (Fredriksson 1984). The toxicity of a given endotoxin decreases after repeated endotoxin administration. This tolerance appears to arise through both non-immunological regulatory and immunological pathways. This first phase of tolerance exhibits no inter-endotoxin specificity, and appears to be caused by the lipid A portion of the endotoxin molecule. The later phase of tolerance, however, is endotoxin specific and is probably in part evoked by an immunological tolerance to the O-antigen polysaccharide chain of the endotoxin (Lindberg et al 1983). The purpose of this project was to investigate the clinical and endocrine response to repeated daily administration of endotoxin in pigs.

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Authors and Affiliations

  1. Pharmacia LEO Therapeutics AB, Uppsala, Sweden

    Chahna Yagoda,  Ann-Christin &  Bylund-Fellenius

  2. Department of Obstetrics and Gynaecology, Swedish University of Agricultural Sciences, S-750 07, Uppsala, Sweden

    Hans Kindahl

Authors
  1. Chahna Yagoda
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  2. Ann-Christin
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  3. Bylund-Fellenius
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  4. Hans Kindahl
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Yagoda, C., Ann-Christin, Bylund-Fellenius et al. Clinical and Endocrine Response to Repeated Daily Administration of Endotoxin in Pigs. Acta Vet Scand 29, 267–269 (1988). https://doi.org/10.1186/BF03548383

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  • DOI: https://doi.org/10.1186/BF03548383

Acta Veterinaria Scandinavica

ISSN: 1751-0147