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Effect of a Glucocorticoid on the Post-Operative Course Following Experimental Orthopaedic Surgery in Dogs

Effekt av et glucokortikoid på det post-operative forløp etter eksperimentell ortopedisk kirurgi på hunder

Acta Veterinaria Scandinavica volume 29, pages 43–49 (1988)Cite this article

Abstract

The capability of a single i.m. injection of betamethasone (Celeston Chronodose®) to modulate a post-operative course was investigated in a placebo-controlled crossover trial with 8 dogs. Two »identical« soft tissue/bone operations were performed on the forelimbs of each animal with an interval of 28 days, to allow a paired comparison of the inflammatory signs and healing process. Significantly less swelling, but not less pain and limping, was observed when the glucocorticoid was administered. No adverse effect of the glucocorticoid was seen on wound and bone healing. The present experimental model is suggested useful for evaluation of anti-inflammatory drug effects in accidental trauma and orthopaedic surgery.

Sammendrag

Effekten av en i.m. injeksjon av betamethason (Celeston Chronodose®) på det post-operative forløp ble undersøkt i en placebo kontrollert overkryssnings-studie med 8 hunder. To »identiske« bløtvevs/hardvevs operasjoner ble utført på forlabbene på hvert dyr med 28 dagers mellomrom slik at en parvis sammenligning av det post-operative inflammatoriske forløp og tilheling kunne utføres. Det ble observert en statistisk signifikant reduksjon i helvelse, men ikke i smerte eller halting. Ingen bieffekter kunne sees på sår eller bentilhelingen etter administrasjon av betamethason. Den presenterte forsøksmodell kan være til nytte for å evaluere legemidlers anti-inflammatoriske virkning på forløpet etter aksidentelle traumer og ortopedisk kirurgiske inngrep.

References

  • Album B, Olsen I, Løkken P: Bilateral surgical removal of impacted mandibular third molar teeth as a model for drug evaluation: A test with oxyp-henbutazone (Tanderil®). Int. J. Oral Surg. 1977, 6, 177–189.

    Article  CAS  Google Scholar 

  • Allgöwer M, Perren S: The importance of inflammation in surgery. In: Bengmark, S. (ed) Inflamma-tionen inom kirurgin. A Lindgren & Söner AB, Göteborg 1967, pp. 10–20.

    Google Scholar 

  • Arrigoni-Martelli E: Screening and assessment of antiinflammatory drugs. Meth. Find. Exp. Clin. Pharmcol. 1979, 1, 157–177.

    CAS  Google Scholar 

  • Blunt J W, Plotz C M, Lattes P, Howes E L, Meyer K, Ragan C: Effect of cortisone on experimental fractures in the rabbit. Proc. Soc. Exp. Biol. Med. 1950, 73, 678–681.

  • Colen L B, Crawley WA, Buncke HJ: Effect of parenteral steroids on edema in replanted rat legs. Plast. Reconstr. Surg. 1979, 63, 830–883.

    Article  CAS  Google Scholar 

  • Haynes R C, Murad F: Adrenocorticotropic hormone; Adrenocortical steroids and their synthetic analogs; Inhibitors of adrenocortical steroid biosynthesis. In Gilman, A. G., Goodman, L. S. & A. Gilman (eds) The Pharmacological basis of therapeutics. Bailliere Tindall, London 1980, p. 1466–1496.

    Google Scholar 

  • Huskisson E C: Non-narcotic analgesics. In Wall P. D. & R. Melzack (eds) Textbook of pain. Churchill Livingstone, Edinburgh 1984, pp. 505–513.

    Google Scholar 

  • Løkken P, Olsen I, Bruaset I, Norman-Pedersen K: Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation: A test with ibuprofen. Eur. J. Clin. Pharmacol. 1975, 8, 209–216.

    Article  Google Scholar 

  • Løkken P, Skjelbred P: Analgesic and anti-inflammatory effects of paracetamol evaluated by bilateral oral surgery. Brit J. Clin. Pharmacol. 1980, supp 10, 253S–260S.

    Google Scholar 

  • Løkken P, Skjelbred P: Aspirin or paracetamol? Lancet, 1981, ii, 1346–1347.

    Article  Google Scholar 

  • Marek J, Blaha V: Traumatic oedema of the rat ear pinna: Its morphology and affection by some anti-inflammatory agents. Int. J. Tiss. React. 1980, 2, 95–206.

    Google Scholar 

  • Ryan G B, Majno: Acute inflammation. A review. Am. J. Pathol. 1977, 86, 185–276.

    CAS  Google Scholar 

  • Schiller R, DeSilva JA: Postoperative steroid injection: The first seventy-two hours of bone healing. J. Am. Podiat. Assoc. 1979, 69, 364–366.

    Article  CAS  Google Scholar 

  • Sissons HA, Hadfield G J: The influence of cortisone on the repair of experimental fractures in the rabbit. Brit. J. Surg. 1951, 39, 172–178.

    Article  CAS  Google Scholar 

  • Skjelbred P: The effects of acetylsalicylic acid on swelling, pain and other events after surgery. Brit. J. Clin. Pharmocol. 1984, 17, 379–384.

    Article  CAS  Google Scholar 

  • Skjelbred P, Løkken P: Post-operative pain and inflammatory reaction reduced by injection of a corticosteroid. A controlled trial in bilateral oral surgery. Eur. J. Clin. Pharmacol. 1982 a, 21, 391–396.

    Article  CAS  Google Scholar 

  • Skjelbred P, Løkken P: Reduction of pain and swelling by a corticosteroid injected 3 hours after surgery. Eur. J. Clin. Pharmacol. 1982 b, 23, 141–146.

    Article  CAS  Google Scholar 

  • Skjelbred P, Løkken P: Effects of naloxone on postoperative pain and steroid-induced analgesia. Eur. J. Clin. Pharma col. 1983, 15, 221–226.

    CAS  Google Scholar 

  • Swartz S L, Dluhy R G: Corticosteroids: Clinical pharmacology and therapeutic use. Drugs. 1978, 16, 238–255.

    Article  CAS  Google Scholar 

Download references

Acknowledgement

This work was supported by the Norwegian Agency for International Development (NORAD). The authors are grateful to L. Sandvik, MSc, for performing the statistical analysis.

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Authors and Affiliations

  1. Department of Clinical Studies, Faculty of Veterinary Medicine, University of Nairobi, P. O. Box, 29053, Kabete, Nairobi, Kenya

    S. W. Mbugua, L. A. Skoglund, P. Skjelbred & P. Løkken

  2. Institute of Pharmacology, University of Oslo, Oslo, Norway

    S. W. Mbugua, L. A. Skoglund, P. Skjelbred & P. Løkken

  3. Department of Pharmacology and Toxicology, Norwegian College of Veterinary Medicine, Oslo, Norway

    S. W. Mbugua, L. A. Skoglund, P. Skjelbred & P. Løkken

Authors
  1. S. W. Mbugua
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  2. L. A. Skoglund
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  3. P. Skjelbred
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  4. P. Løkken
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Mbugua, S.W., Skoglund, L.A., Skjelbred, P. et al. Effect of a Glucocorticoid on the Post-Operative Course Following Experimental Orthopaedic Surgery in Dogs. Acta Vet Scand 29, 43–49 (1988). https://doi.org/10.1186/BF03548390

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Acta Veterinaria Scandinavica

ISSN: 1751-0147