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Different Tissue Uptake after Administration of Proline and Hydroxyproline in Neonatal Piglets
Skillnader i väunadsupptag efter parenteral tillförsel av prolin och hydroxyprolin till nyfödda grisar
Acta Veterinaria Scandinavica volume 18, pages 501–508 (1977)
Abstract
Using whole body autoradiography and impulse counting technique, distribution of intramuscularly administered 14C-DL-hydroxyproline and 14C-L-proline in newborn piglets was compared. The main excretion route of hydroxy-proline was via the kidneys. Hydroxyproline or its metabolic products were excreted at quite another rate by the liver than was proline. Skeletal muscles and myocardium showed a lowered ratio of proline to hydroxyproline. A difference in favour of hydroxyproline in passing the blood-brain barrier was shown. Contrary to proline hydroxyproline yielded a low 14C-level in the skeletal tissues. The possibilities of an incomplete hydroxylation of proline as an aetiological factor in the origin of skeletal disorders are discussed.
Sammanfattning
En jämförande undersökning avseende vävnadsupptag och utsöndring har gjorts på nyfödda grisar efter injektion av 14C-märkt L-prolin och DL-hydroxyprolin. Autoradiografi på hela djur samt impulsräkning på vävnader, organ och kroppsvätskor har utförts. Huvuddelen av parenteralt tillfört hydroxyprolin elimineras renalt. DL-hydroxyprolin eller dess metaboliter utsöndras snabbare via levern än motsvarande från prolin härledda substanser. Av de båda aminosyrorna gav hydroxyprolin högre 14C-upptag i muskelvävnad och hjärnsubstans än prolin. Till skillnad från prolin visade hydroxyprolin låg affinitet till benvävnaden. Möjligheterna av en rubbning i hydroxyleringen av prolin som orsak till vissa sjukdomar i skelettet på husdjur diskuteras.
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Bengtsson, G., Hakkarainen, J. Different Tissue Uptake after Administration of Proline and Hydroxyproline in Neonatal Piglets. Acta Vet Scand 18, 501–508 (1977). https://doi.org/10.1186/BF03548413
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DOI: https://doi.org/10.1186/BF03548413