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Genetic Variations in the Antibody Response in Young Bulls

Acta Veterinaria Scandinavica volume 18, pages 572–574 (1977)Cite this article

Abstract

Considerable evidence for the existence of a direct genetic control of the immune response has been presented during recent years. Experimental work with rodents are the main basis for this evidence. The first study on genetic variations in the antibody response was carried out by Gorer & Schütze (1938). Later Cinader (1960) published detailed considerations about the specificity and inheritance of the antibody response. In mice it has been demonstrated that a few dominant immune response (Ir) genes determine the ability to produce antibodies against certain specific antigens (McDevitt & Tyan 1968). The magnitude of the response is probably under the influence of polygenes, which are not associated with Ir genes. This theory is supported by selection for high and low antibody production in mice (Biozzi et al. 1972).

References

  • Foggie A.: Studies on the infectious agent of tick-borne fever in sheep. J. Path. Bact. 1951, 63, 1–15.

    Article  CAS  Google Scholar 

  • Foggie A.: The effect of tick-borne fever on the resistance of lambs to Staphylococci. J. comp. Path. 1956, 66, 278–285.

    Article  CAS  Google Scholar 

  • Foggie A.: Studies on the relationship of tick-bite to tick pyaemia of lambs. Ann. trop. Med. Parasit. 1959, 53, 27–34.

    Article  CAS  Google Scholar 

  • Foster W. N. M. & A. E. Cameron: Observations on ovine strains of tick-borne fever. J. comp. Path. 1970 a, 80, 429–436.

    Article  CAS  Google Scholar 

  • Foster W. N. M. & A. E. Cameron: Observations on the functional integrity of neutrophil leucocytes infected with tick-borne fever. J. comp. Path. 1970 b, 80, 487–491.

    Article  CAS  Google Scholar 

  • Gordon W. S. A. Brownlee, D. R. Wilson & J. MacLeod: The epizootio-logy of louping-ill and tick-borne fever with observations on the control of these sheep diseases. Symp., Zool. Soc, London 1962, No. 6, 1–27.

    Google Scholar 

  • Meulemans O.: Determination of total protein in spinal fluid with sulphosalisylic acid and trichloroacetic acid. Clin. chim. Acta 1960, 5, 757–761.

    Article  CAS  Google Scholar 

  • Waldeland H.: Toxoplasmosis in sheep. Haematological, serological and parasitological studies. Acta vet. scand. 1977, 18, 248–256.

    Article  CAS  Google Scholar 

  • Øverås J.: Studies on immunity to tick-borne fever in sheep in Norway. Nord. Vet.-Med. 1962, 14, 620–630.

    Google Scholar 

  • Øverås J.: Sjukdom hos sau på Ixodes ricinus infisert beite. (Diseases in sheep kept on Ixodes ricinus infected pastures). Norsk Vet.-T. 1972, 83, 561–567.

    Google Scholar 

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  1. The National Veterinary Institute, Postbox 8156, Oslo Dep., Oslo 1, Oslo, Norway

    Øystein Lie

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  1. Øystein Lie
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Lie, Ø. Genetic Variations in the Antibody Response in Young Bulls. Acta Vet Scand 18, 572–574 (1977). https://doi.org/10.1186/BF03548424

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Acta Veterinaria Scandinavica

ISSN: 1751-0147