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Saponin Adjuvants. IV. Evaluation of The Adjuvant Quil a in the Vaccination of Cattle Against Foot-And-Mouth Disease

Acta Veterinaria Scandinavica volume 18, pages 349–360 (1977)Cite this article

Abstract

The saponin adjuvant Quil A has been investigated in the vaccination of cattle against foot-and-mouth disease. Using a Frenkel type vaccine a dose-response relationship has been established between Quil A and neutralizing antibody titres. Ten ml of vaccine was combined with 0, 50, 200, 800, and 3200 µg of Quil A. The combinations were each injected into 4 animals. The local reaction on the site of injection produced by injection of the vaccine alone and in combination with different doses of Quil A has been estimated. On this basis a therapeutical dose at 1 mg of Quil A has been estimated to combine maximum adjuvant effect with a minimum of adverse reactions. This dose has been tested in the vaccination of cattle with FMD vaccines derived from BHK suspension cell virus of type O and A respectively. The vaccines were tested in 10 ml and 5 ml doses with or without Quil A, and each in 4 animals. It is concluded that Quil A is a valuable adjuvant for use in the induction of neutralizing antibodies against foot-and-mouth disease in cattle.

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  1. The State Veterinary Institute for Virus Research, Lindholm, DK-4771, Kalvehave, Denmark

    K. Dalsgaard, Merethe H. Jensen & K. J. Sørensen

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  1. K. Dalsgaard
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  2. Merethe H. Jensen
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  3. K. J. Sørensen
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Dalsgaard, K., Jensen, M.H. & Sørensen, K.J. Saponin Adjuvants. IV. Evaluation of The Adjuvant Quil a in the Vaccination of Cattle Against Foot-And-Mouth Disease. Acta Vet Scand 18, 349–360 (1977). https://doi.org/10.1186/BF03548432

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Acta Veterinaria Scandinavica

ISSN: 1751-0147