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The Effect of O,O-DIMETHYL-O-(2,4,5-Trichlorophenyl) Phosphorothioate (Fe Nc H Lor Phos) On Cholinesterases in the Blue Fox (Alopex Lagopus)
Acta Veterinaria Scandinavica volume 18, pages 408–415 (1977)
Abstract
Four blue fox bitches were used in the experiments. Two foxes were given fenchlorphos in the feed, one 100 mg/kg body weight and the other 200 mg/kg daily for 30 days. The maximum inhibition of plasma Cholinesterase was 65 and 69 %, respectively. The corresponding values of the erythrocyte acetylcholinesterase were 43 and 63 %.
For the third bitch given 0.4 mg/kg as a single dose i.v. the effect was only measurable as a small transient decrease of the plasma Cholinesterase level.
Eighty % of the plasma Cholinesterase of the fourth fox, given 500 mg/kg as a single oral dose, was inhibited on the third day. The erythrocyte acetylcholinesterase activity level only showed a slight decline. This fox vomited during feeding the day after administration.
Symptoms as salivation, tremors, diarrhea, pinpoint pupils and respiratory distress were never seen in any of the foxes.
It was concluded that fenchlorphos administration in the feed in doses recommended to dogs is well tolerated by healthy foxes as far as Cholinesterase inhibition is concerned.
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Søli, N.E., Andersen, R.A., Skaare, J.U. et al. The Effect of O,O-DIMETHYL-O-(2,4,5-Trichlorophenyl) Phosphorothioate (Fe Nc H Lor Phos) On Cholinesterases in the Blue Fox (Alopex Lagopus). Acta Vet Scand 18, 408–415 (1977). https://doi.org/10.1186/BF03548438
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DOI: https://doi.org/10.1186/BF03548438