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Butylhydroxyanisol (BHA), Butylhydroxytoluene (BHT) and Ethoxyquin (EMQ) Tested for Mutagenicity

Butylhydroksytoluen, butylhydroksyanisol og ethoxyquin testet for mutagenitet

Acta Veterinaria Scandinavica volume 18, pages 187–193 (1977)Cite this article

Abstract

The antioxydants butylhydroxyanisol (BHA), butylhydroxytoluene (BHT) and ethoxyquin (EMQ) were tested for mutagenicity in the so-called “Ames test”. The test was performed with and without the addition of microsomal mixed function oxidase system from rat liver. The compounds were found not to be mutagenic in this test. At high concentration of BHA and EMQ toxic effects on the growth of the bacteria were observed.

Sammendrag

Antioksydantene butylhydroksytoluen (BHT), butylhydroksyanisol (BHA) og ethoxyquin (EMQ) er undersøkt med hensyn til muta- genisitet i den såkalte “Ames test” med negativt resultat. Undersøkel- sen har vært utført både med og uten tilsetning av mikrosomalt blan- det oksydase system fra rottelever fra dyr indusert med PGB. Ved høye konsentrasjoner av butylhydroksyanisol og ethoxyquin kan man ob- servere toksisk virkning på bakterienes vekst.

References

  • Ames, B. N., W. E. Durston, E. Yamasaki & F. D. Lee: Carcinogens are mutagens: A simple test system combining liver homo-genates for activation and bacteria for detection. Proc. nat. Acad. Sei. (Wash.) 1973, 70, 2281–2285.

    Article  CAS  Google Scholar 

  • Ames, B. N., J. McCann Sc E. Yamasaki: Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutation Res. 1975, 31, 347–364.

    Article  CAS  Google Scholar 

  • Bridges, B, A.: Short term screening test for carcinogens. Nature (Lond.) 1976, 261, 195–200.

    Article  CAS  Google Scholar 

  • Matter, B. E.: Problems of testing drugs for potential mutagenicity. Mutation Res. 1976, 38, 243–258.

    Article  CAS  Google Scholar 

  • McCann, J., E. Choi, E. Yamasaki & B. N. Ames: Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals. Proc. nat. Acad. Sci. (Wash.) 1975, 72, 5135–5139.

    Article  CAS  Google Scholar 

  • Rubin, H. & B. N. Ames: Carcinogenicity tests. Science 1976, 191, 241–244.

    Article  CAS  Google Scholar 

  • Sivak, A.: The Ames assay. Science 1976, 192, 272–273.

    Article  Google Scholar 

  • Stoltz, D. R., L. A. Poirier, C. C. Irving, H. F. Stich, J. H. Weisburger & H. C. Grice: Evaluation of short-term tests for carcinogenicity. Toxicol, appl. Pharmacol. 1974, 29, 157–180.

    Article  CAS  Google Scholar 

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Acknowledgments

The excellent technical assistance of Randi Hag in gratefully acknowledged.

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Authors and Affiliations

  1. Department of Food Hygiene, Veterinary College of Norway, Postbox 8146, Oslo Dep., Oslo 1, Norway

    Per Erik Joner

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  1. Per Erik Joner
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Joner, P.E. Butylhydroxyanisol (BHA), Butylhydroxytoluene (BHT) and Ethoxyquin (EMQ) Tested for Mutagenicity. Acta Vet Scand 18, 187–193 (1977). https://doi.org/10.1186/BF03548447

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Acta Veterinaria Scandinavica

ISSN: 1751-0147