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Prostaglandin Release at Dexamethasone Induced Parturitions in Cows
Prostaglandinfrisläppning vid dexamethason-inducerad förlossning hos ko
Acta Veterinaria Scandinavica volume 18, pages 257–265 (1977)
Abstract
Three cows of the Swedish Red and White Breed (SRB) were used in the experiment. Cow no. 1 pregnant for 247 days, was given 20 mg dexamethasone twice with an interval of 48 hrs. Cows nos. 2 and 3, each pregnant for 254 days, received 20 mg of dexamethasone twice with an interval of 24 hrs. The cows delivered normal living calves 153, 138 and 137 hrs., respectively, after the second injection of dexamethasone. Blood samples were drawn from the jugular vein every third hour during the experimental period and the samples were analyzed for estrone, progesterone and 15-keto-13,14-dihydroprostaglandin F2α. Following the dexamethasone injections there was a continuous increase in the blood plasma levels of estrone followed by a sharp decrease in conjunction with parturition. The blood plasma level of progesterone showed a slow but continuous decrease until about 24 hrs. before delivery when a marked drop occurred. The levels of the prostaglandin metabolite increased gradually until about 24 hrs. prior to delivery. This was followed by an abrupt rise, and high levels of the prostaglandin metabolite were recorded for up to four days following parturition. It is concluded that the estrone increase preceded that of the prostaglandin metabolite and that the final drop in the progesterone was synchronous with the final rise of the prostaglandin metabolite level.
Sammanfattning
Tre dräktiga kor av SRB-ras ingick i försöket. Ko nr. 1, dräktig 247 dagar, gavs 20 mg dexamethason i.m. med 48 timmars intervall. Ko nr. 2 och 3 gavs samma dos i.m. men med 24 timmars intervall. Behandlingen resulterade i prematur förlossning 153, 138 och 137 timmar efter sista Injektionen. Under försöksperioden uttogs blod- prover var 3:e tirnma. Blodproverna analyserades med avseende påöstron, progesteron samt huvudmetaboliten till prostaglandin F2α hos ko, 15-keto-l3,14-dihydroprostaglandin F2α. Den perifera blodplasma- koncentrationen av östron ökade efter dexametasonbehandlingen från cirka 0.5 ng/ml till maximalt 3–5 ng/ml som uppmättes under 24-tim- marsperioden närmast före förlossningen. Efter partus sjönk perifera blodplasmanivån av Östron snabbt till värden under 0.5 ng/ml. Perifera blodplasmanivån av progesteron sjönk långsamt och gradvis från cirka 5–8 ng/ml till cirka 3 ng/ml vilket uppmättes ungefär 24 timmar före förlossningen. Därefter sjönk progesteronnivån kraftigt och värden nära noli registrerades strax före och i samband med förlossningen. Koncentrationen av 15-keto-l 3,14-dihydroprostaglandin F2α ökade långsamt fram till ungefär 24 timmar före förlossningen då en snabb ökning av koncentrationen noterades samtidigt med den kraf- tiga progesteronsänkningen. Sammanfattningsvis kan konkluderas att östronuppgången föregick ökningen av prostaglandinmetaboliten och att den slutliga progesteronsänkningen inträffade samtidigt med att koncentrationen av prostaglandinmetaboliten ökade kraftigt. Den höga nivån av prostaglandinmetaboliten kvarstod i upp til fyra dygn efter förlossningen.
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Lindell, JO., Kindahl, H. & Edqvist, LE. Prostaglandin Release at Dexamethasone Induced Parturitions in Cows. Acta Vet Scand 18, 257–265 (1977). https://doi.org/10.1186/BF03548454
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DOI: https://doi.org/10.1186/BF03548454