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Thyroxine, Triiodothyronine and Reverse-Triiodothyronine Concentrations in Blood Plasma in Relation to Lactational Stage, Milk Yield, Energy and Dietary Protein Intake in Estonian Dairy Cows

Acta Veterinaria Scandinavica volume 38, pages 339–348 (1997)Cite this article

Abstract

Average levels of thyroxine (T4), triiodothyronine (T3) and reverse-triiodothyronine (rT3) in blood plasma of 159 Estonian Red and Estonian Black and White cows were 55.2 nmol/L, 1.78 nmol/L and 0.25 nmol/L respectively. Animals were grouped according to stage of lactation. The T4 level was significantly lower during the early stage of lactation (45.1 nmol/L), compared with later stages, but increased as the stage of lactation progressed (late stage of lactation–56.7, dry cows 64.3 nmol/L). The T3 level was significantly higher at the late stage of lactation (1.93 nmol/L) compared with the early stage of lactation (1.71 nmol/L) and level in dry cows (1.71 nmol/L). rT3 showed a trend similar to that found for T4 (lowest plasma concentration in early lactation, 0.19; highest in the dry period, 0.33; late lactation, 0.24 nmol/L). Levels of all thyroid hormones were negatively related to the daily milk yield (T4− r = −.51, rT3 − r = −.47, calculated thyroid index as rT3*T3*T4− r = −.52, for all p<.0001; T3 − r = −.32, p<.01). Plasma thyroid hormone concentrations were affected by energy and dietary protein intake. Differences were found in thyroid hormone levels between the 2 breeds and between summer and winter holding periods for Estonian Red cows, which could all be explained by differences in the feeding level and daily milk yield. It is suggested that maintaining low levels of thyroid hormones in early lactation may be one of the dairy cow’s mechanisms of reducing metabolic demand.

References

  • Akasha MA, Anderson RR: Thyroxine and triiodothyronine in milk of cows, Goats, Sheep and Guinea Pigs. Proc. the Society for Experimental Biol, and Med. 1984,777,360–371.

    Article  Google Scholar 

  • Akasha MA, Anderson RR, Ellersieck M, Nixon DA: Concentration of thyroid hormones and prolactin in dairy cattle serum and milk at three stages of lactation. J. Dairy Sei. 1987, 70, 271–276.

    Article  CAS  Google Scholar 

  • Anderson RR: Secretion rates of thyroxine and triiodothyronine in dairy cattle. J. Dairy Sei. 1971, 54, 1195–1198.

    Article  CAS  Google Scholar 

  • Bines JA, Hart IC, Morant SV: Endocrine control of energy metabolism in the cow: Diurnal variation in the concentrations of hormones and metab-olites in the blood plasma of beef and dairy cow. Hormone and metabolic Res. 1983, 1, 330–334.

    Article  Google Scholar 

  • Bitman J, Kahl S, Wood DL, Lefcourt AM: Circadian and ultradian rhythms of plasma thyroid hormone concentrations in lactating dairy cows. Am. J. Physiol. 1994, 266(6, 2), R1797–R1803.

    CAS  PubMed  Google Scholar 

  • Blum JW, Kunz P, Leuenberger H: Thyroid hormones, blood plasma metabolites and haematological parameters in relationship to milk yield in dairy cows. Anim. Prod. 1983, 36, 93–104.

    CAS  Google Scholar 

  • Christopherson RJ, Gonyou HW, Thompson JR: Effects of temperature and feed intake on plasma concentration of thyroid hormones in beef cattle. Can. J. Sei. 1979, 59,655–661.

    CAS  Google Scholar 

  • Collier RJ, McNamara JP, Wallace CR, Dehoff MH: A review of endocrine regulation of metabolism during lactation. J. Anim. Sei. 1984, 59, 498–510.

    Article  CAS  Google Scholar 

  • Coppock SE: Energy nutrition and metabolism of the lactating dairy cow. J. Dairy Sei. 1985, 68, 3403–3410.

    Article  Google Scholar 

  • Ekins R: Roles of serum thyroxine-binding proteins and maternal thyroid hormones in fetal development. The Lancet i, 1985,1129–1132.

    Google Scholar 

  • El-Nouty FD, Johnson HD, Kamal TH, Hassan GA, Salem MH: Some hormonal characteristics of high and low yielding Holstein cows and water buffaloes located in temperate and subtropical environments. Beitr. trop. Landwirtsch. Vet Med. 1989,27, H.4, 461–468.

    CAS  Google Scholar 

  • Facuda H, Ohshima K, Mori M, Kobayashi I, Greer MA: Sequential changes in the pituitary-thyroid axis during pregnancy and lactation in the rat. Endocrinology 1980, 107, 1711–1716.

    Article  Google Scholar 

  • Gerloff BJ, Herdt TH, Wells WW, Nachreiner RF, Emery RS: Inosital and hepatic lipidosis. II. Effect of inositol supplementation and time from parturition on serum insulin, thyroxine and triiodothyronine and their relationship to serum and liver lipids in dairy cows. J. Anim. Sei. 1986, 62, 1693–1702.

    Article  CAS  Google Scholar 

  • Hart IC, Bines JA, Morant SV: Endocrine control of energy metabolism in the cow. Correlation of hormones and metabolites in high and low yielding cows for stage of lactation. J. Dairy Sei. 1979, 62, 270–274.

    Article  CAS  Google Scholar 

  • Hassan GA, El-Nouty FD, Salem MH: Relationship between milk intensity and pituitary-thyroid function in water buffaloes. J. Agric. Sei., Cambridge 1985, 104, 473–475.

    Article  Google Scholar 

  • Hennemann G: In: Thyroid hormone metabolism (Hennemann, G., ed.) Marcel Deccer, New York, 1986, pp. 277–295.

  • Jindal SK, Ludri RS: Circulating thyroxine (T4) and triiodothyronine (T3) levels in lactating crossbred cows and buffaloes as affected by stage of lactation and time of sampling. Int. J. Anim. Sei. 1991, 6, 122–127.

    Google Scholar 

  • Johnson HD, Van Jonack WJ: Effect of environmental and other stress on blood hormone pattern in lactating animals. J. Dairy Sei. 1976, 59, 1603–1617.

    Article  CAS  Google Scholar 

  • Kaneko J J: Thyroid function. In: Clinical biochemistry of domestic animals. Ed. J.J. Kaneko. Fourth edition. Academic Press, New York, 1989, pp. 630–649.

    Google Scholar 

  • Kunz P, Blum JW: Effect of pre- and postpartum energy intake on blood plasma levels of hormones and metabolites in cows. Int. J. Vit. Res. 1981, 2, 195–196.

    Google Scholar 

  • Kunz PL, Blum JW, Hart IC, Bickel H, Landis J: Effects of different energy intakes before and after calving on food intake, performance and blood hormones and metabolites in dairy cows. Anim. Prod. 1985,40,219–231.

    CAS  Google Scholar 

  • Magdub AB, Johnson HD: Estimation of thyroid function in regard to milk production by measures of plasma thyroxine and thyroxine turnover. J. Dairy Sei. 1977, 60 (Suppl. 1), 105 (Abstr.).

    Google Scholar 

  • Melnik BE, Budantsev AI, Korotkov AA, Veutserova EC: Correlation between thyroid gland and ovarian function in cows during the resumption of ovarian activity. Izvestii Akademiya Nauk Mol-dovskoi SSR, Seriya Biologicheskie i khimiches-kie Nauk, 1989,3, 40–44 (in Russian).

    Google Scholar 

  • Moe PW, Tyrrell HF, Flatt WP: Partial efficiency of energy use for maintenance, lactation, body gain and gestation in the dairy cow. In: Energy metabolism of farm animals. Proc. Fifth Symposium of Eur. Assoc. for Animal Prod. 1970, pp. 65–68. Vitsnau, Switzerland.

    Google Scholar 

  • Nehring K, Beyer M, Hoffmann B: Feed tables. Futtermitteltabellenwerk. 2. Auflage- Berlin, VEB Deutsche Landwirtschaftsverlag, 1972,452 p. (in German).

    Google Scholar 

  • Nixon DA, Akasha MA, Anderson RR: Free and total thyroid hormones in serum of Holstein cows. J. Dairy Sei. 1988, 71, 1152–1160.

    Article  CAS  Google Scholar 

  • Oll Ü: Allowances of the nutrient requirements for dairy cattle. Proceedings of the Animal Nutrition Conference, 26-27 May, 1994 in Tartu, Estonia. Estonian Research Institute of Animal Breeding and Veterinary Science, 1994, 141–144.

    Google Scholar 

  • Oll Ü, Karis V, Sikk V: Instruction to estimate nutritive values of feedstuffs. Söötade toiteväärtuse arvutamise juhend koos abitabelitega. Tartu, EPA, 1974, 100 p. (in Estonian).

    Google Scholar 

  • Refsal KR., Nachreiner RF, Anderson CR: Relationship of season, herd, lactation, age and pregnancy with serum thyroxine and triiodothyronine in Holstein cows. Dom. An. Endocrin. 1984, 1(3), 225–234.

    Article  CAS  Google Scholar 

  • Ronge H, Blum J, Clement C, Jans F, Leuenberger H, Binder H: Somatomedin C in dairy cows related to energy and protein supply and to milk production. Anim. Prod. 1988, 47, 165–183.

    CAS  Google Scholar 

  • Rudas P: Reverse-triiodothyronine (rT3) in domesticated animals. Acta Physiol. Acad. Sei. Hung. 1980, 56, 74.

    Google Scholar 

  • Slebodzinski AB: Perinatal thyroid activity in farm animals and the role of iodocompounds in maternal milk. Endocr. Exper. 1986, 20, 229–246.

    CAS  Google Scholar 

  • Strbak V, Tomsik F: Thyroid levels in cow maternal and fetal sera during last trimester of pregnancy. Endocr. Experimentalis, 1988, 22, 113–116.

    CAS  Google Scholar 

  • Thompson-Ball T, Anderson RR: Thyroid hormone concentrations in blood and milk of dairy cows. J. Dairy Sei. 1980, 63 (Suppl. 1), 82–83.

    Google Scholar 

  • Tiirats T: Comparison of different commercial immunoassay kits used for the measurement of total thyroxine (TT4), triiodothyronine (TT3) and Cortisol in dairy cattle plasma. I Estonian-Finnish Meeting on Physiology, Nov. 13-14, 1992. Sei. prog, and abstr. Tartu, 1992, 29–35.

    Google Scholar 

  • Tucker HA: Lactation and its hormonal control. The Physiology of Reproduction. Edited by E. Knobil and J. Neill {etet al.}. Raven Press, Ltd., New York. 1988, pp. 2235–2254.

    Google Scholar 

  • Tveit B, Lingaas F, Standal N: Thyroid function in heifers measured by hormone levels before and after injection of thyrotropin releasing hormone. Acta Agric. Scand. 1990, 40, 175–181.

    Article  CAS  Google Scholar 

  • Visser TJ: Metabolism of thyroid hormone. In Hormones and their actions, Part 1. B.A. Cookie, R.J.B. King and H.J. van der Molen (eds), Elsevier Science Publishers BV (Biomedical Division), 1988, pp. 81–103.

    Chapter  Google Scholar 

  • Walsh DS, Veseli JA, Mahadevan S: Relationship between milk production and circulating hormones in dairy cows. J. Dairy Sei. 1980, 63, 290–294.

    Article  CAS  Google Scholar 

Download references

Acknowledgment

The author gratefully acknowledges the financial support of the Swedish University of Agricultural Sciences and the Department of Clinical Chemistry at the Faculty of Veterinary Medicine, where this study was carried out.

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  1. Department of Clinical Chemistry, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden

    T. Tiirats

  2. Department of Physiology, Faculty of Veterinary Medicine, Estonian Agricultural University, Kreutzwaldi 64, EE 2400, Tartu, Estonia

    T. Tiirats

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Tiirats, T. Thyroxine, Triiodothyronine and Reverse-Triiodothyronine Concentrations in Blood Plasma in Relation to Lactational Stage, Milk Yield, Energy and Dietary Protein Intake in Estonian Dairy Cows. Acta Vet Scand 38, 339–348 (1997). https://doi.org/10.1186/BF03548480

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Acta Veterinaria Scandinavica

ISSN: 1751-0147