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Effect of 19-Norandrostenololylaurate on Serum Testosterone Concentration, Libido, and Closure of Distal Radial Growth Plate in Colts
Acta Veterinaria Scandinavica volume 38, pages 59–67 (1997)
Abstract
The long-term effect of anabolic steroid was investigated in 3 experiments. In experiment I, 500 mg of 19-norandrostenololylaurate was given to 5 colts and a dose of 100 mg to another 5 colts every 3rd week. Six colts served as untreated controls. The animals were 12-16 months old at the start, and 24 months at the end of treatment. In experiment II, a dose of 1 mg/kg was given every 3rd week to 4 colts and 0.3 mg/kg every week to another 4 colts. Six colts served as controls. The colts were treated from 7 months to 12 months of age. In experiment III, 1 mg/kg of steroid was given every 3rd week to 3 foals between 3 and 8 months of age. Three foals were used as controls. Libido and hCG-induced serum testosterone concentrations were studied after the cessation of treatments, up to 3 or 4 years of age. Closure of the right distal radial growth plate was determined between 21 and 36 months of age. Treated colts had lower testosterone levels 4.5 months after cessation of treatment in experiment I (p<0.001) and experiment II (p<0.05) when compared with the corresponding control groups. Two years after treatments in experiment I, hCG-induced testosterone levels were higher in treated colts than in untreated controls, but the difference was not statistically significant. The treatments had no effect on libido. The anabolic steroid treatment did not cause premature closure of epiphyseal growth plates in any of the experiments, but closure appeared to be delayed. It was concluded that anabolic steroids have long term effects on reproduction. Their influence on serum testosterone can last for years after cessation of treatment, and they can delay the closure of growth plates which can cause increased susceptibility to cartilage injury during exercise.
References
Blanchard TL: Some effects of anabolic steroids - especially on stallions. Comp. Cont. Educ., 1985, 7, 372–380.
Burns PJ, Jawad MJ, Weld JM, Kaufman WC, Witherspoon DM, Wilson EA, Douglas RH: Effects of season, age and increased photoperiod on reproductive hormone concentrations and testicular diameters in thoroughbred stallions. Eq. vet. Sci., 1984, 4, 202–208.
Carson RL, Thompson FN: Effects on an anabolic steroid on the reproductive tract in the young stallion. J. Eq. Med. Surg., 1979, 3, 221–224.
Clay CM, Squires EL, Amann RP, Nett TM: Influences of season and artificial photoperiod on stallions: luteinizing hormone, follicle-stimulating hormone and testosterone. J. Anim. Sci., 1988, 66, 1246–1255.
Davis LE: Anabolic steroids in the horse. J. Amer, vet. med. Ass., 1981, 179, 278–280.
Dietz O, Nagel E, Schwede H: Zur Problematik der Epiphysenreifiing beim Pferd (Problems in growth plate closure in the horse). Prakt. Tierarzt, 1988, 69, 21–27.
Ganjam VK: Episodic nature of the A4-ene and A5- ene steroidogenic pathways and their relationships to the adreno-gonadal axis in stallions. J. Reprod. Fert., 1979, Suppl. 27, 67–71.
Garcia MC, Ganjam VK, Blanchard TL, Brown E, Hardin K, Elmore RG, Youngquist RS, Loch WE, Ellersieck MR, Balke JM: The effects of stanozolol and boldenone undecylenate on plasma testosterone and gonadotropins and on testis histology in pony stallions. Theriogenology, 1987, 28, 109–119.
Herring DS: Radiographic evaluation of the distal radial physis of horses treated with anabolic steroids. Proc. Symp. Anab. Steroids in Eq. Med., Columbia, Missouri, 1981, 18–20.
Maher JM, Squires EL, Voss JL, Shideler RK: Effect of anabolic steroids on reproductive function of young mares. J. Amer. vet. med. Ass., 1983, 183, 519–524.
McDonnel SM, Murray SC: Bachelor and harem stallion behavior and endocrinology. Biol. Reprod. Mono 1, 1995, 577–590.
Saastamoinen M, Koskinen E: Influence of quality of dietary protein supplement and anabolic steroids on muscular and skeletal growth of foals. Anim. Prod., 1993, 56, 135–144.
Silberzahn P, Zwain I, Guerin P, Benoit E, Jouany JM, Bonnaire Y: Testosterone response to human chorionic gonadotropin injection in the stallion. Eq. vet. J., 1988, 20, 61–63.
Squires EL, Bemdtson WE, Hoyer JH, Pickett BW, Wallach SJR: Restoration of reproductive capacity of stallions after suppression with exogenous testosterone. J. Anim. Sci., 1981, 53, 1351–1359.
Squires EL, Todter GE, Bemdtson WE, Pickett BW: Effect of anabolic steroids on reproductive function of young stallions. J. Anim. Sci., 1982, 54, 576–582.
Tobin T: Pharmacology review: The anabolic steroid androgen group of drugs. J. Equine Med. Surg., 1978, 2, 163–165.
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Koskinen, E., Katila, T. Effect of 19-Norandrostenololylaurate on Serum Testosterone Concentration, Libido, and Closure of Distal Radial Growth Plate in Colts. Acta Vet Scand 38, 59–67 (1997). https://doi.org/10.1186/BF03548508
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DOI: https://doi.org/10.1186/BF03548508