Skip to main content
Download PDF
  • Published:

Pancreatic Duct Obstruction in the Pig: Light Microscopy of Chronic Pancreatitis

Obstruktion av ductus pancreaticus hos svin: Ljusmikroskopiska undersökningar av kronisk pankreatit

Acta Veterinaria Scandinavica volume 28, pages 285–289 (1987)Cite this article

Abstract

Morphological changes of pancreatic tissue in young pigs caused by surgical ligation of the main pancreatic duct are described. Nineteen animals from 6 to 7 weeks in age were operated on and necropsied 3 or 6 to 8 weeks later. Twelve pigs developed a pronounced chronic pancreatitis with complete exocrine insufficiency. Of the 7 animals failing to develop ectasia of pancreatic ducts, 2 died due to surgical complications. In addition, 3 pigs were sham-operated and served as controls. In macroscopical studies it was observed that in the pronounced pancreatitis cases the ligated duct was greatly dilated by a clear watery fluid. Only remnants of pale and firm grandular tissues were seen around the ectatic ducts. Microscopically, typical changes of chronic pancreatitis were noted. Complete disappearance of acini was followed by ductular cell proliferations. Glandular tissues were divided into lobuli by fibrotic tissues and fat cells. The wall of the main pancreatic duct was greatly thickened and fibrotic, presenting intensely proliferating ductular cells and round cell infiltrates. Furthermore, enlarged endocrine islets surrounded by connective tissue fibres were seen.

Sammanfattning

Morfologiska alterationer av pankreasvävnaderna rapporteras hos växande svin opererade med ligation av huvudpancreasgången. 19 djur blev opererade i 6–7 veckors ålder och obducerades 3 eller 6–8 veckor senare.

12 svin utvecklade den kroniska fasen av sjukdomen med komplett exocrin insuffisiens. Av 7 djur, som inte uppvisade kronisk pankreatit, dog 2 i komplikationer som tillstötte efter operationen. Dessutom blev 3 svin shamopererade och använda som kontrolldjur.

Vid makroskopiska studier av kroniska pankreatiter kunde man observera att den ligerade gången var mäktigt utvidgad med klar serös vätska. Bara små områden med ljus och fast körtelvävnad kunde ses omkring de förstorade gångarna. Vid mikroskopiska undersökningar observerades alterationer typiska för kronisk pankreatit. Acinära vävnader hade fördärvats och var kompletterade med duktcellproliferationer. Körtelvävnaderna var separerade i lobuli med fibrotiska vävnader och fettceller. Huvudpankreasgångens vägg var mycket förtjockad och fibrotisk med rikliga proliferationer av duktceller och rundcelleinfiltrationer. Vidare obseverades förstorade endokrina öar omgivna av bindvävsfibrer.

References

  • Boquist L, Edström C: Ultrastructure of pancreatic acinar and islet parenchyma in rats at various intervals after duct ligation. Virchows Arch. Abt. A Path. Anat. 1970,349, 69–79.

    Article  CAS  Google Scholar 

  • Capello C, Solda E: The endocrine cells of the pig gastrointestinal mucosa and pancreas. Arch, hi-stol. jap. 1972,35, 1–29.

    Article  Google Scholar 

  • Churg A, Richter W: Early changes in the exocrine pancreas of the dog and rat after ligation of the pancreatic duct. A light and electron microscopic study. Amer. J. Path. 1971,63, 521–546.

    CAS  PubMed  Google Scholar 

  • Eder M, Gedick P: Lehrbuch der AUgemeinen Pathologie und der Pathologischen Anatomie (Textbook of General Pathology and Pathological Anatomy). Springer-Verlag, Berlin, Heidelberg, New York 1974.

    Book  Google Scholar 

  • Grònlund Α-M, Nikander S: Personal communication, 1984.

    Google Scholar 

  • Horaguchi A, Cobb L, Marineola F, Azumi Ν, Mer-rei R: Islet recovery in chronic pancreatitis. J. Surg. Res. 1983,35, 277–282.

    Article  CAS  Google Scholar 

  • Idezuki Y, Goets F, Lillehei R: Late effect of pancreatic duct ligation on beta cell function. Amer. J. Surg. 1969,117, 33–39.

    Article  CAS  Google Scholar 

  • Rahko T, Grönlund Α-M, Kalima Τ V, Saloniemi Η: A new animal model for exocrine pancreatic insufficiency. Path. Res. Pract. 1985, 180, 309.

    Google Scholar 

  • Schroder T, Lempinen M, Nordling S, Kinnunen P: Chlorpromazine treatment of experimental acute fulminant pancreatitis in pigs. Eur. surg. Res. 1981,13, 143–151.

    Article  CAS  Google Scholar 

  • Zeligs J, Janoff A, Dumont A: The course and nature of acinar cell death following pancreatic ligation in the guinea pig. Amer. J. Path. 1975,80, 203–225.

    CAS  PubMed  Google Scholar 

  • Walters M, Archer J, Papadimitriou J: Pancreatic duct obstruction: Ultrastructural morphology of the acute phase. Pathology 1969,1, 95–104.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Livestock Hygiene, College of Veterinary Medicine and The Second Department of Surgery, University of Helsinki, Hämeentie 57, SF-00550, Helsinki 55, Finland

    Timo Rahko, Timo V. Kalima & Hannu Saloniemi

Authors
  1. Timo Rahko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Timo V. Kalima
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hannu Saloniemi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rahko, T., Kalima, T.V. & Saloniemi, H. Pancreatic Duct Obstruction in the Pig: Light Microscopy of Chronic Pancreatitis. Acta Vet Scand 28, 285–289 (1987). https://doi.org/10.1186/BF03548595

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03548595

Keywords

Acta Veterinaria Scandinavica

ISSN: 1751-0147