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Pancreatic Duct Obstruction in the Pig: Light Microscopy of Chronic Pancreatitis

Obstruktion av ductus pancreaticus hos svin: Ljusmikroskopiska undersökningar av kronisk pankreatit


Morphological changes of pancreatic tissue in young pigs caused by surgical ligation of the main pancreatic duct are described. Nineteen animals from 6 to 7 weeks in age were operated on and necropsied 3 or 6 to 8 weeks later. Twelve pigs developed a pronounced chronic pancreatitis with complete exocrine insufficiency. Of the 7 animals failing to develop ectasia of pancreatic ducts, 2 died due to surgical complications. In addition, 3 pigs were sham-operated and served as controls. In macroscopical studies it was observed that in the pronounced pancreatitis cases the ligated duct was greatly dilated by a clear watery fluid. Only remnants of pale and firm grandular tissues were seen around the ectatic ducts. Microscopically, typical changes of chronic pancreatitis were noted. Complete disappearance of acini was followed by ductular cell proliferations. Glandular tissues were divided into lobuli by fibrotic tissues and fat cells. The wall of the main pancreatic duct was greatly thickened and fibrotic, presenting intensely proliferating ductular cells and round cell infiltrates. Furthermore, enlarged endocrine islets surrounded by connective tissue fibres were seen.


Morfologiska alterationer av pankreasvävnaderna rapporteras hos växande svin opererade med ligation av huvudpancreasgången. 19 djur blev opererade i 6–7 veckors ålder och obducerades 3 eller 6–8 veckor senare.

12 svin utvecklade den kroniska fasen av sjukdomen med komplett exocrin insuffisiens. Av 7 djur, som inte uppvisade kronisk pankreatit, dog 2 i komplikationer som tillstötte efter operationen. Dessutom blev 3 svin shamopererade och använda som kontrolldjur.

Vid makroskopiska studier av kroniska pankreatiter kunde man observera att den ligerade gången var mäktigt utvidgad med klar serös vätska. Bara små områden med ljus och fast körtelvävnad kunde ses omkring de förstorade gångarna. Vid mikroskopiska undersökningar observerades alterationer typiska för kronisk pankreatit. Acinära vävnader hade fördärvats och var kompletterade med duktcellproliferationer. Körtelvävnaderna var separerade i lobuli med fibrotiska vävnader och fettceller. Huvudpankreasgångens vägg var mycket förtjockad och fibrotisk med rikliga proliferationer av duktceller och rundcelleinfiltrationer. Vidare obseverades förstorade endokrina öar omgivna av bindvävsfibrer.


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Rahko, T., Kalima, T.V. & Saloniemi, H. Pancreatic Duct Obstruction in the Pig: Light Microscopy of Chronic Pancreatitis. Acta Vet Scand 28, 285–289 (1987).

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  • pancreatic duct ligation
  • exocrine pancreatic insufficiency
  • experimental chronic pancreatitis
  • porcine pancreas diseases