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Pulmonary Multinucleate Giant Cells in Dermatosis Vegetans in Swine: Light microscopic and immunohistochemical investigations
Pulmonære multinukleære kjempeceller ved dermatosis vegetans hos gris. Lysmikroskopiske og immunhistokjemiske studier
Acta Veterinaria Scandinavica volume 28, pages 429–433 (1987)
Abstract
Five pigs with dermatosis vegetans (DV), aged 1–28 days, were examined with the purpose of describing the pulmonary changes and to characterize the pulmonary multinucleate giant cells (MGC) and their possible cytogenesis.
No pulmonary changes were present at birth. From 7 days of age, lung changes were characterized by proliferation of alveolar epithelial cells and formation of MGCs. Immunostaining for cytokeratin by a peroxydase–streptavidin method gave a positive reaction in MGCs, bronchial, bronchiolar and alveolar epithelium. MGCs seemed to be formed in the course of alveolar epithelial proliferations, and type-II pneumocytes were proposed as possible precursors.
Sammendrag
Fem griser i alderen 1 til 28 dager med lidelsen dermatosis vegetans (DV) ble undersøkt med henblikk på å beskrive lungeforandringer og spesielt for å gi en morfologisk karakterisering av pulmonære multinukleære kjempeceller (PMK) og deres mulige cytogenese.
Det forelå ingen lungeforandringer ved fødsel. Fra 7 dagers alder var lungeforandringene karakterisert ved proliferasjon av alveole-epitelceller og PMK-dannelser. Ved immunhistokjemiske studier basert på en peroksydase-streptavidin metode ble det påvist positiv reaksjon i PMK, bronkie-, bronkiole- og proliferert alveole epitel.
PMK syntes å dannes i forløpet av alveolære proliferasjoner og type-II pneumocytter ansees som en mulig cellulær opprinnelse.
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Acknowledgment
This study was financially supported by the Norwegian Agricultural Research Council.
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Evensen, Ø., Bratberg, B. Pulmonary Multinucleate Giant Cells in Dermatosis Vegetans in Swine: Light microscopic and immunohistochemical investigations. Acta Vet Scand 28, 429–433 (1987). https://doi.org/10.1186/BF03548611
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DOI: https://doi.org/10.1186/BF03548611