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Pulmonary Multinucleate Giant Cells in Dermatosis Vegetans in Swine: Light microscopic and immunohistochemical investigations

Pulmonære multinukleære kjempeceller ved dermatosis vegetans hos gris. Lysmikroskopiske og immunhistokjemiske studier


Five pigs with dermatosis vegetans (DV), aged 1–28 days, were examined with the purpose of describing the pulmonary changes and to characterize the pulmonary multinucleate giant cells (MGC) and their possible cytogenesis.

No pulmonary changes were present at birth. From 7 days of age, lung changes were characterized by proliferation of alveolar epithelial cells and formation of MGCs. Immunostaining for cytokeratin by a peroxydase–streptavidin method gave a positive reaction in MGCs, bronchial, bronchiolar and alveolar epithelium. MGCs seemed to be formed in the course of alveolar epithelial proliferations, and type-II pneumocytes were proposed as possible precursors.


Fem griser i alderen 1 til 28 dager med lidelsen dermatosis vegetans (DV) ble undersøkt med henblikk på å beskrive lungeforandringer og spesielt for å gi en morfologisk karakterisering av pulmonære multinukleære kjempeceller (PMK) og deres mulige cytogenese.

Det forelå ingen lungeforandringer ved fødsel. Fra 7 dagers alder var lungeforandringene karakterisert ved proliferasjon av alveole-epitelceller og PMK-dannelser. Ved immunhistokjemiske studier basert på en peroksydase-streptavidin metode ble det påvist positiv reaksjon i PMK, bronkie-, bronkiole- og proliferert alveole epitel.

PMK syntes å dannes i forløpet av alveolære proliferasjoner og type-II pneumocytter ansees som en mulig cellulær opprinnelse.


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This study was financially supported by the Norwegian Agricultural Research Council.

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Evensen, Ø., Bratberg, B. Pulmonary Multinucleate Giant Cells in Dermatosis Vegetans in Swine: Light microscopic and immunohistochemical investigations. Acta Vet Scand 28, 429–433 (1987).

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  • lungs
  • syncytia formations
  • cytokeratins
  • type-II pneumocytes