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Studies on the Progression of Aleutian Disease in Mink
Undersøgelse af udviklingen af plasmacytose hos mink
Acta Veterinaria Scandinavica volume 29, pages 315–321 (1988)
Abstract
One hundred ninetyfive male ADV-negative mink, including 79 pairs of brothers, were followed in their response to natural ADV-infection caused by mating with ADV-positive females and under epidemic conditions. Special attention was drawn to the development of progressive versus non-progressive Aleutian disease. This was done by plasmaelectrophoresis, detection of antibodies to ADV, and finally by macroscopical examination of mink organs at pelting time. We found that the progression of Aleutian disease presumably is under some genetic influence. We also found indication of differences in the response to ADV depending on how the infection was introduced. Mating to positive females (low virus concentration) resulted in significantly higher proportion of non-progressive responders than infection under epidemic conditions (high virus concentration).
Sammendrag
Ethundredeogfemoghalvfems plasmacytose-negative hanmink, inclusive 79 broderpar, blev fulgt med henblik på deres reaktion på naturlig plasmacytose-infektion forårsaget dels ved parring med plasmacytose-positive hunner og dels under epidemiske omstændigheder. Særlig opmærksomhed blev rettet mod udviklingen af progressiv kontra ikke-progressiv plasmacytose. Dette undersøgtes ved plasmaelektroforese, sporing af plasmacytoseantistof og slutteligt ved makroskopisk undersøgelse af minkorganer. Vi fandt, at udviklingen af plasmacytose sandsynligvis er genetisk influeret. Vi fandt også indikation for, at mink reagerer forskelligt på infektion med plasmacytosevirus og at forskellen er afhængig af infektionsmåden. Pairing med positive hunner (lav viruskoncentration) gav signifikant højere ratio af ikke-progressive forløb af plasmacytose end infektion under epidemiske forhold (høj viruskoncentration).
References
Aasted B: Aleutian disease of mink. Virology and immunology. Acta path, microbiol. immunol. scand. Sect. C 1985, suppl. 287, vol. 93.
Aasted B, Alexandersen S, Cohn A, Hansen M: Counter current line absorption immunoelec-trophoresis in an alternative diagnostic screening test to counter current immunoelectropho-resis in Aleutian disease (AD) eradication programs. Acta vet. scand. 1986, 27, 410–420.
An SH, Ingram DG: Detection of inapparent Aleutian disease virus infection in mink. Amer. J. vet. Res. 1977, 38, 1619–1624.
An SH, Ingram DG: Transmission of Aleutian disease from mink with inapparent infections. Amer. J. vet. Res. 1978, 39, 309–313.
An SH, de Pauli FJ, Wright P, Ingram DG: Characteristics of inapparent Aleutian disease virus infection in mink. Res. Vet. Sci. 1978, 24, 200–204.
Bloom, ME, Race RE, Wolfinbarger JB: Characterization of Aleutian disease virus as a parvovirus. J. Virol. 1980, 35, 836–843.
Cho HJ, Ingram DG: Antigen and antibody in Aleutian disease in mink. I. Precipitation reaction by agar-gel electrophoresis. J. Immunol. 1972, 108, 555–557.
Ingram DG, Cho HJ: Aleutian disease in mink: Virology, immunology and pathogenesis. Rheumatology 1974, 1, 74–91.
Larsen AE, Porter DD: Pathogenesis of Aleutian disease of mink: Identification of nonpersi-stent infections. Infect. Immun. 1975, 11, 92–94.
Lodmell DL, Portis JL: Immunologic and genetic aspects of Aleutian disease. In: Immunological defects in laboratory animals 2, (eds. Ger-schwin and merchant) Plenum press, NY & London 1981, pp 39–75.
Porter DD, Larsen AE, Porter HG: Aleutian disease of mink. Adv. Immunol. 1980, 29, 261–286.
Svensen PJ, Weeke B, Johansson B-G: Chemicals, solutions, equipment and general procedures. Scand. J. Immunol. 1983, Suppl. 10, vol. 17, pp 3–20.
Acknowledgments
Knud Christensen, Department of Animal Genetics, Royal Veterinary and Agricultural University, Copenhagen, Denmark, was most helpful in contributing his expertise in genetics to the planning and evaluation phases of this research which we gratefully acknowledge. However, responsibility for any error or omission rests solely with the authors.
The technical assistance of Ms. Else Bang Larsen and Ms. Anne Friis Petersen is greatly acknowledged. This work was supported by grants from the Danish Veterinary and Agricultural Research Council, the Danish Fur Breeders Association Research Foundation, Andre Simon S. A., and Sys-plan A/S.
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Aasted, B., Hauch, H. Studies on the Progression of Aleutian Disease in Mink. Acta Vet Scand 29, 315–321 (1988). https://doi.org/10.1186/BF03548624
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DOI: https://doi.org/10.1186/BF03548624