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Monoclonal Antibodies Against Surface Antigens of Vibrio Anguillarum Serogroup 02

Monoklonale antistoffer mod overflade-antigener hos Vibrio anguillarum

Acta Veterinaria Scandinavica volume 29, pages 363–368 (1988)Cite this article

Abstract

Monoclonal antibodies to Vibrio anguillarum 0-group 2 (MAB 02) were used to compare the cell surface determinants of V. anguillarum 0-groups 1 and 2, and V. ordalii. In the homologous system a significant reactivity was found, while MAB 02 clones showed a very low-graded cross-reactivity to V. anguillarum 01 and V. ordalii. The importance of these aspects in the selection of adequate vaccine strains is discussed, with an emphasis on the improvement of vibriosis vaccines.

Sammendrag

Monoklonale antistoffer mod Vibrio anguillarum O-gruppe 2 (MAB 02) blev fremstillet for at kunne sammenligne overflade-antigene determinanter på V, anguillarum 01 og 02 samt V. ordalii. I det homologe system fandtes en kraftig reaktion mellem MAB 02 og 02-stammerne, derimod var der meget lidt krydsreaktion med V. anguillarum 01 og V. ordalii. Dette forhold har stor betydning, når der skal udvælges stammer til vaccineproduktion, og med denne baggrund diskuteres mulighederne for forbedring af vibriose-vaccinerne.

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Acknowledgments

The financial support of Nordisk Ministerr&d is greatly appreciated.

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Authors and Affiliations

  1. Ballerup and Department of Hygiene and Microbiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark

    Jens Laurits Larsen & Ivan Svendsen

  2. Institute of Hygiene and Microbiology, Royal Veterinary and Agricultural University, 13 BOlowsvej, DK-1870, Frederiksberg C, Denmark

    Jens Laurits Larsen & Ivan Svendsen

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  1. Jens Laurits Larsen
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  2. Ivan Svendsen
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Larsen, J.L., Svendsen, I. Monoclonal Antibodies Against Surface Antigens of Vibrio Anguillarum Serogroup 02. Acta Vet Scand 29, 363–368 (1988). https://doi.org/10.1186/BF03548630

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  • DOI: https://doi.org/10.1186/BF03548630

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Acta Veterinaria Scandinavica

ISSN: 1751-0147