Skip to main content
Download PDF
  • Published:

Phenylbutazone and Flunixin Meglumine Fail to Show Beneficial Effects on Bovine Subclinical Mastitis

Acta Veterinaria Scandinavica volume 29, pages 501–503 (1988)Cite this article

Abstract

Inflammation is caused by the release of chemical mediators from tissues and migra-tory cells. These mediators include leuco-trienes and prostaglandins (PGs), which are generated from arachidonic acid (Vane & Botting 1987). Elevated concentrations of arachidonic acid metabolites have been found in experimental and spontaneous ma-stitis, which indicates that these substances may have a role in the pathophysiologic process of mastitis (Anderson et al. 1985, Atroshietal 1986).

References

  • Anderson KL, Kindahl H, Petroni H, Smith AR, Gustafsson BK: Arachidonic acid metabolites in milk of cows during acute coliform masti-tis. Amer. J. vet. Res. 1985, 46, 1573–1577.

    CAS  PubMed  Google Scholar 

  • Anderson KL, Smith AR, Shanks RD, Davis LE, Gustafsson BK: Efficacy of flunixin meglu-mine for treatment of endotoxin-induced bo-vine mastitis. Amer. J. vet. Res. 1986, 47, 1366–1372.

    CAS  PubMed  Google Scholar 

  • Atroshi F, Parantainen J, Sankari S, Österman T: Prostaglandins and glutathione peroxidase in bovine mastitis. Res. Vet. Sci. 1986, 40, 361–366.

    Article  CAS  Google Scholar 

  • Eberhardson B, Olsson G, Appelgren LE, Jacobs-son SO: Pharmacokinetic studies of phenyl-butazone in cattle. J. vet. Pharmacol. Therap. 1979, 2, 31–37.

    Article  CAS  Google Scholar 

  • Hardee GE, Smith JA, Harris SJ: Pharmacokine-tics of flunixin meglumine in the cow. Res. Vet. Sci. 1985, 39, 110–112.

    Article  CAS  Google Scholar 

  • Lees P, Higgins J: Clinical pharmacology and therapeutic uses of non-steroidal anti-inflam-matory drugs in the horse. Equine Vet. J. 1985,77,83–96.

    Article  Google Scholar 

  • Martin K, Andersson L, Stridsberg M, Wiese B, Appelgren LE: Plasma concentration, mam-mary excretion and side-effects of phenyl-butazone after repeated oral administration in healthy cows. J. vet. Pharmacol.Therap. 1984, 7, 131–138.

    Article  CAS  Google Scholar 

  • Mattila T, Sandholm M: Milk plasmin, N-acetyl-ß-D-glucosaminidase, and antitrypsin as deter-minants of bacterial replication rates in whey. J. Dairy Sci. 1986, 69, 670–675.

    Article  CAS  Google Scholar 

  • Sedgwick AD, Lees P, Dawson J, May SA: Cellu-lar aspects of inflammation. Vet. Res. 1987, 120, 529–535.

    CAS  Google Scholar 

  • Vane J, Botting R: Inflammation and the me-chanism of action of anti-inflammatory drugs. The FASEB J. 1987, 1, 89–96.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Helsinki, Finland

    Satu Pyörälä, Jaana Pätilä & Markus Sandholm

  2. Ambulatory Clinic, College of Veterinary Medicine, SF-04840, Hautjarvi, Finland

    Satu Pyörälä

Authors
  1. Satu Pyörälä
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jaana Pätilä
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Markus Sandholm
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pyörälä, S., Pätilä, J. & Sandholm, M. Phenylbutazone and Flunixin Meglumine Fail to Show Beneficial Effects on Bovine Subclinical Mastitis. Acta Vet Scand 29, 501–503 (1988). https://doi.org/10.1186/BF03548648

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03548648

Acta Veterinaria Scandinavica

ISSN: 1751-0147