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Visna Virus Meningoencephalomyelitis in Goats
Meningoencephalomyelit hos getter förorsakad av visnavirus
Acta Veterinaria Scandinavica volume 22, pages 315–330 (1981)
Abstract
A progressive paresis was encountered in herds of Swedish goats. The symptoms developed during a period of weeks or months, and were initially often seen as a weakness of the hind limbs before the animals became paralytic. The development and the histopathological lesions of the disease in the GNS and the lungs were similar to those of visna in sheep. In vitro grown choroid plexus cells, prepared from affected goats, showed foci of polykaryocytes. Electron microscopy revealed the presence of particles morphologically similar to those of sheep visna virus (SVV). Goats experimentally infected with the goat visna virus (GVV) developed GNS lesions similar to those of visna in sheep and became seropositive to SVV. The results of complement fixation tests, carried out on sera from 11 goat herds, showed a coincidence between seropositiveness and the occurrence of disease in one and the same herd. Using the ELISA method, an average of 80 % of the goats in 5 herds were found to be seropositive to GVV.
Sammanfattning
Progressiv pares på visades hos svenska getter. Symtombilden började med svaghet i bakbeneη och utvecklades långsamt under veckor eller månader. Sjukdomsförloppet och de histop atologiska förändringarna i centrala nervsystemet och lungorna var i överensstämmelse med vad som beskrivits vid visna hos får. i vävnadskulturer av choroidplexusceller från sjuka getter påvisades polykaryocyter. Vid elektronmikroskopisk undersökning iakttogs partiklar, som morfologiskt liknade visnavirus hos får (SVV). Hos getter, som experimentellt infekterades med getvisnavirus (GVV), utvecklades skador i centrala nervsystemet av samma utseende som vid visna. De blev serologiskt positiva mot SVV. Serologisk undersökning med komplementfixeringstest av getter från elva besättningar visade att det föreligger en korrelation mellan förekomst av positiva testresultat och sjukdomsfall i besätningarna. Med ELISA visades att i medeltal 80 procent av getterna i fem testade besätningar var serologiskt positiva mot GVV.
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Sundquist, B., Jönsson, L., Jacobsson, SO. et al. Visna Virus Meningoencephalomyelitis in Goats. Acta Vet Scand 22, 315–330 (1981). https://doi.org/10.1186/BF03548657
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DOI: https://doi.org/10.1186/BF03548657