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Milk Antitrypsin Activity During Clinical and Experimental Bovine Mastitis

Antitrypsinaktivitet i mjölk vid kliniska och experimentella mastiter

Acta Veterinaria Scandinavica volume 22, pages 360–368 (1981)Cite this article

Abstract

Milk trypsin-inhibitor levels were followed during clinical and experimental endotoxin-induced mastitis. Milk trypsin-inhibitor level proved to be a good indicator of mastitis, closely relating to milk BSA values. The trypsin-inhibitor pattern in the quarter milk samples during mastitis closely resembled the pattern of BSA, which indicates that the trypsin-inhibitor is blood derived and diffuses to the mammary gland lite albumin. The timing of the increase in the trypsin-inhibitor into the endotoxin infused quarter closely matched with the increase in body temperature, heart rate, decrease in blood leucocytes and increase in somatic cells. Serum zinc and iron showed a decrease a few hours later.

Sammanfattning

Mjölkets trypsin-inhibitorkapacitet analyserades vid kliniska och experimentella endotoxin-inducerade mastiter. Trypsin-inhibitorkapacitet synes vara en bra miastit-indikator av liknande varde, som en bestämning av mjölkets albumin (BSA).

Vid en longitudinell undersökning av mastitkor visade antitrypsin aktiviteten och albuminmängden en överstämmande korrelation, vilket indikerar att trypsin-inhibitorerna diffunderar från blodet på samma sätt som BSA.

Vid endotoxin inducerad mastit blev mjölkets trypsin-inhibitorhalt maximalt nästan samtidigt med ökningen av temperaturen, pulsen och mjölkets cellhalt. Zink- och järnhalten i serum sjönk efter några timmar.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology and the Ambulatory Clinic, College of Veterinary Medicine, and the State Veterinary Medical Institute, P.O. Box 6, SF-00551, Helsinki 55, Finland

    T. Honkanen-Buzalski, T. Katila & M. Sandholm

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  1. T. Honkanen-Buzalski
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  2. T. Katila
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  3. M. Sandholm
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Honkanen-Buzalski, T., Katila, T. & Sandholm, M. Milk Antitrypsin Activity During Clinical and Experimental Bovine Mastitis. Acta Vet Scand 22, 360–368 (1981). https://doi.org/10.1186/BF03548661

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Acta Veterinaria Scandinavica

ISSN: 1751-0147