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Table 1 Summary of clinical and clinicopathological data in 28 dogs with chronic enteropathy

From: Urinary and faecal N-methylhistamine concentrations do not serve as markers for mast cell activation or clinical disease activity in dogs with chronic enteropathies

Dog

Age (years)

Sex

CCECAI

Therapy

Fecal NMH

Urinary NMH

Mast cells (mean number/10 hpf)

Histopathology duodenum

≤191(ng/g)

≤136(ng/mg creatinine)

TB

IHC

WSAVA score

Infiltrate

1

9y 4 m

FN

12

D, IS

74

176

16.6

31.4

3

LP

2

1y 5 m

MN

6

D, M

-

46

3.2

21

0

N/A

3

3y 8 m

MN

5

D, M

40

86

22.6

22.6

1

LP

4

2y 1 m

F

7

D, M

0

32

2

16

1

neut

5

1y 3 m

M

5

D

-

474

1.4

10

0

N/A

6

10y

MN

9

D, M

-

69

11.6

16.4

3

LP

7

1y 6 m

FN

6

D, IS

165

108

1.2

2.6

0

N/A

8

7y 9 m

FN

7

D, M, IS

789

186

2.6

13.4

2

-

9

5y 8 m

MN

9

D

57

132

9.2

28

0

N/A

10

3y 1 m

MN

3

D, M

139

95

10

11.8

1

-

11

6y 5 m

MN

4

D

1451

62

6.4

10.2

5

LP, eos

12

2y 7 m

MN

6

D, M

0

249

8

27.4

5

eos

13

4y 11 m

FN

7

D, IS

54

112

2.2

2

1

-

14

8y

M

13

D, M

272

114

3.8

9.8

4

LP

15

2y 6 m

M

7

D, M

98

68

1.6

12.2

5

LP*

16

4y

F

8

D, IS

1150

163

0.2

8.6

5

eos

17

4y 4 m

M

9

D, IS

29

19

1

4.2

1

-

18

3y 10 m

FN

6

D

0

53

0.4

7.8

2

LP

19

1y 1 m

MN

5

D

0

100

8.8

4.2

9

LP, eos**

20

1y 2 m

MN

5

D

0

99

3.6

9.2

1

-

21

6y 2 m

FN

9

D, IS

0

43

0.1

1.2

3

LP

22

3y 3 m

FN

2

D

0

46

0.4

2.2

3

LP*

23

6y 6 m

M

6

D

131

53

2.8

10.4

6

LP

24

8y 2 m

FN

9

D

105

5

9.2

6.6

0

N/A

25

4y 5 m

M

11

D, IS

41

76

-

-

-

-

26

1y 1 m

F

6

D, M, IS

-

52

-

-

-

-

27

8y 7 m

FN

4

IS

0

116

-

-

-

-

28

4y

FN

6

D, M

38

151

-

-

-

-

Median

  

6

 

47.5

90.5

3

10.1

2

 

Min

  

2

 

0

5

0.1

1.2

0

 

Max

  

13

 

1451

474

22.6

31.4

9

 
  1. CCECAI, canine chronic enteropathy clinical activity index; NMH, N-methylhistamine; hpf, high-power field; TB, toluidine blue; IHC, immunohistochemistry (tryptase); WSAVA, World Small Animal Veterinary Association; FN, female neutered; MN, male neutered; D, diet (novel or hydrolysed protein); M, metronidazole; IS, immunosuppressive drug (prednisolone, azathioprine, cyclosporine); LP, lymphoplasmacytic; neut, neutrophilic; eos, eosinophilic; *, moderate; **, marked; N/A, not applicable; − data missing.
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Acta Veterinaria Scandinavica

ISSN: 1751-0147