The distribution of pathogens and their antimicrobial susceptibility patterns among canine surgical wound infections in Sweden in relation to different risk factors

Windahl, Ulrika; Bengtsson, Björn; Nyman, Ann-Kristin; Holst, Bodil Ström

doi:10.1186/s13028-015-0102-6

Acta Veterinaria Scandinavica

Table 1 Antimicrobial susceptibility of isolated pathogens in the canine surgical site infections

From: The distribution of pathogens and their antimicrobial susceptibility patterns among canine surgical wound infections in Sweden in relation to different risk factors

		Antimicrobials tested ^a
		AMP	PEN	CEP	OXA	CTX	ERY	CLI	ENR	GEN	TET	T-S
*Staphylococcus pseudintermedius n = 90*	BP-S	ß-lact.^b	ß-lact.^b	≤2	≤0.25	NR^f	≤0.5	≤0.5	≤0.5	≤2	≤4	≤0.5/9.5
	% S	20.0	20.0	95.6	NR^d	NR^f	76.7	NR^d	94.4	93.3	73.3	75.6
	MIC ₅₀	NA^c	NA^c	≤2	≤0.5	NR^f	≤0.5	≤1	≤0.12	≤2	≤1	≤0.5/9.5
	MIC ₉₀	NA^c	NA^c	2	≤0.5	NR^f	>4	>4	0.25	≤2	>8	1/18
*Staphylococcus aureus n = 15*	BP-S	ß-lact.^b	ß-lact.^b	≤2	≤2	NR^f	≤0.5	≤0.5	≤0.5	≤2	≤4	≤0.5/9.5
	% S	20.0	20.0	100	100	NR^f	100	NR^d	100	100	93.3	93.3
	MIC ₅₀	NA^c	NA^c	≤2	≤0.5	NR^f	≤0.5	≤1	≤0.12	≤2	≤1	≤0.5/9.5
	MIC ₉₀	NA^c	NA^c	≤2	≤0.5	NR^f	≤0.5	≤1	0.25	≤2	≤1	≤0.5/9.5
*Staphylococcus schleiferi coagulans n = 7*	BP-S	ß-lact.^b	ß-lact.^b	≤2	≤25	NR^f	≤0.5	≤0.5	≤0.5	≤2	≤4	≤0.5/9.5
	% S	14.3	14.3	100	NR^d	NR^f	71.4	85.7	100	100	85.7	100
	MIC ₅₀	NA^c	NA^c	≤2	≤0.5	NR^f	≤0.5	≤1	0.25	≤2	≤1	≤0.5/9.5
	MIC ₉₀	NR^e	NR^e	NR^e	NR^e	NR^f	NR^e	NR^e	NR^e	NR^e	NR^e	NR^e
beta haemolytic *Streptococcus* spp. n = 47	BP-S	≤0.25	≤0.12	≤2	NR^f	NR^f	≤0.25	≤0.5	≤0.5	≤2	≤2	≤0.5/9.5
	% S	NR^d	100	100	NR^f	NR^f	NR^d	NR^d	17.0	0.0	66.0	100
	MIC ₅₀	≤1	≤0.12	≤2	NR^f	NR^f	≤0.5	≤1	1	8	2	≤0.5/9.5
	MIC ₉₀	≤1	≤0.12	≤2	NR^f	NR^f	≤0.5	≤1	2	8	>8	≤0.5/9.5
*Escherichia coli n = 20*	BP-S	≤0.25	-^f	≤2	NR^f	≤1	NR^f	NR^f	≤0.5	≤2	≤4	≤0.5/9.5
	% S	NR^d	-^f	5.0	NR^f	95.0	NR^f	NR^f	100	100	80.0	90.0
	MIC ₅₀	4	-^f	>4	NR^f	≤0.25	NR^f	NR^f	≤0.12	≤2	8	≤0.5/9.5
	MIC ₉₀	>16	-^f	>4	NR^f	≤0.25	NR^f	NR^f	≤0.12	≤2	16	≤0.5/9.5
*Pasteurella multocida n = 6*	BP-S	≤0.25	≤0.25	≤2	NR^f	NR^f	NR^f	NR^f	≤0.5	≤2	≤2	≤0.5/9.5
	% S	NR^f	100	100	NR^f	NR^f	NR^f	NR ^f	100	100	100	100
	MIC ₅₀	≤1	≤0.12	≤2	NR^f	NR^f	2	≤1	≤0.12	≤2	≤1	≤0.5/9.5
	MIC ₉₀	NR^e	NR^e	NR^e	NR^e	NR^f	NR^e	NR^e	NR^e	NR^e	NR^e	NR^e

Antimicrobial susceptibility presented as the percentage of susceptible isolates (%S) and as MIC₅₀ and MIC₉₀ values (mg/L), i.e. the MIC required to inhibit 50% and 90% of the isolates respectively. Breakpoints used to define isolates as susceptible (BP-S) are according to CLSI [22].
^aAmpicillin (AMP), penicillin (PEN), cephalothin (CEP), oxacillin (OXA), cefotaxime (CTX), erythromycin (ERY), clindamycin (CLI), enrofloxacin (ENR ), gentamicin (GEN), tetracycline (TET), trimethoprim- sulfamethoxazole (T-S).
^bResistant to penicillin and ampicillin through beta-lactamase production (ß-lact).
^cNot applicable (NA), as susceptibility is based on ß-lactamase production.
^dNot relevant (NR) as breakpoints used to define isolates as susceptible (BP-S) [22] is below the range of concentrations tested.
^eNot relevant (NR) as the small number of isolates precludes calculation of MIC₉₀.
^fNot relevant (NR) as no BP-S is available.

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ISSN: 1751-0147

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