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Table 2 Overview of the 29 studies included in the review

From: C-reactive protein: quantitative marker of surgical trauma and post-surgical complications in dogs: a systematic review

Study focus

Reference

n

Sex, age (years), BW (kg)

Surgical procedure

Surgical category

Primary outcome

Pre-surgery inflammation

Method for CRP analysis

Observational studies of CRP measured post-surgery

[18]

27

F, 2–10, 5–30

Ovariohysterectomy

1

CRP

+

TIAb

[19]

20

F, 2–4, 12–30

Ovariohysterectomy

1

CRP, WBC, Temp

−

ELISAc

[20]

49

F, 0.75–12, 10–64

Ovariohysterectomy

1

CRP

−

TIAd

[21]

5

M, 5–7, 14–21

Orchidectomy

1

CRP

−

TIAb

[22]

6

F, 2–6, NS

Ovariohysterectomy

1

CRP

−

ELISAc

[23]

20

F, 4–12, NS

Ovariohysterectomy

1

CRP

+

ELISAc

[24]

16

F/M, 0.25–3, 4–39

Balloon valvuloplasty of pulmonic stenosis

1

CRP

−

ELISAc

[25]

20

F, 3–12, NS

Ovariohysterectomy

1

CRP

±

ELISAc

[9]

19

NS, NS, NS

5 different procedures

1 and 2

CRP

±

ELISA, RPLAe

Evaluation of new surgical methods

[26]

12

F/M, NS, 10–34

Double balloon endoscopy of intestine

3

Clinical outcome

−

NS

[27]

12

NS, NS, 7–9

Endoscopic transumbilical thoracic lung biopsy

3

Clinical outcome

−

ELISAf

[28]

14

NS, NS, 7–11

Transtracheal endoscopy of thorax

3

Clinical outcome

−

NS

[29]

7

M, NS, 13.2a

Laparoscopic assisted colopexy and sterilization

3

Clinical outcome

−

IPg

[30]

5

NS, NS, 20–28

Endoscopic ovariectomy

3

Clinical outcome

−

NS

[31]

7

F, 2.5a, 9a

Laparoscopic-sutured gastropexy

3

CRP

−

ELISAh

Comparison of different kinds of surgery

[32]

28

NS, NS, 7–10

Transoral vs. conventional thoracoscopy

3

Perioperative stress

−

ELISAf

[33]

32

F/M, 0.5–8, NS

Sterilization, 3 techniques

1 and 3

CRP

−

TIAj

[34]

20

NS, NS, 6–11

Transoral vs. conventional thoracoscopy

2 and 3

Perioperative stress

−

ELISAf

[35]

8

NS, 0.8–5, 15–25

Laparoscopic vs. laparotomic colopexy

1 and 3

Perioperative stress

−

ELISAi

[36]

24

NS, adult, 25–30

Sternotomy and pericardiotomy vs. atriotomy

2

Perioperative stress

−

ELISAb

[37]

30

F, NS, 11–38

Ovariectomy, 3 techniques

1 and 3

Perioperative stress

−

ELISAh

[38]

43

F/M, >0.6, NS

Ovariohysterectomy vs. hemilaminectomy

1 and 2

CRP

±

TIAj

[39]

15

F, NS, 17.4a

Splenectomy, 3 techniques

2 and 3

Perioperative stress

−

LATk

Changes in CRP due to different treatments?

[40]

16

F, 3–14, 17.3a

Ovariohysterectomy

1

CRP

−

MIAl

[41]

18

F, 1.5–4, 12–20

Ovariohysterectomy

1

CRP

−

ELISAb

[42]

45

F, 2.7a, 11.9a

Ovariohysterectomy

1

CRP

−

ELISAm

[43]

46

F/M, 2–3, 20.7a

Ovariohyster- and orchiectomy

1

Perioperative stress

−

ELISAb

[44]

20

F/M, 9.5a, 16.3a

Ovariohyster- and orchiectomy

1

CRP

−

ELISAb

[45]

12

F/M, 1.5–10, 12–45

Cruciate ligament rupture and patella luxation

2

Perioperative stress

+

ELISAb

  1. C-reactive protein (CRP). F female dogs, M male dogs, NS not specified
  2. aMean. Surgical categories: 1 minor/moderate surgery, 2 major surgery, 3 endoscopic procedures
  3. bTurbidimetric immunoassay, CRP OSR 6147 Olympus Life and Material Science Europe GMbH, Lismeehan, O’Callaghan’s Mills, Co., Clare, Ireland
  4. cEnzyme-linked immunosorbent assay,Tridelta Development Limited, Kildare, Ireland
  5. dTurbidimetric immunoassay, Randox Laboratories Ltd., Crumlin, UK
  6. eRPLA: Reversed passive latex agglutination
  7. fEnzyme linked immunosorbent assay, PharMingen, BD Biosciences, San Diago, USA
  8. gImmunoprecipitation, Reagent Konelab ThermoElectron, Cergy Pontoise, France
  9. hEnzyme linked immnosorbent assay, Life diagnostics, Inc, West Chester, USA
  10. iEnzyme linked immunosorbent assay, unspecified
  11. jTurbidimetric immunoassay, Bayer CRP TIA, Newbury, UK
  12. kLatex agglutination turbidimetry, Huma Tex CRP, In Vitro Diagnostica, Itabira, Brazil
  13. lMagnetic immunoassay, LifeAssays Canine CRP Test Kit, Sweden
  14. mEnzyme linked immunosorbent assay, Alpco Diagnostics, Salem, NH, USA