Antimicrobial
|
Organism
|
N
|
N (%) > ECOFF
|
MIC mg/l, % of isolates
|
ECOFFa
|
---|
Benzylpenicillin
| | | |
≤0.06
|
0.12
|
0.25
|
0.5
|
1
|
2
|
4
|
8
|
≥16
| | | | |
0.125
b
|
S. chromogenes
|
48
|
14 (29.2)
|
68.8
|
2.1
|
4.2
|
6.3
|
12.5
|
6.3
| | | | | | | | |
S. epidermidis
|
78
|
58 (74.4)
|
23.1
|
2.6
|
6.4
|
9.0
|
12.8
|
15.4
|
9.0
|
11.5
|
10.3
| | | | | |
S. haemolyticus
|
37
|
24 (64.9)
|
32.4
|
2.7
|
16.2
|
27.0
|
13.5
|
5.4
|
2.7
| | | | | | | |
S. simulans
|
78
|
3 (3.8)
|
93.6
|
2.6
|
2.6
| | |
1.3
| | | | | | | | |
Oxacillin
| | | | | | |
≤0.5
|
1
|
2
|
4
|
≥8
| | | | | |
1.0
|
S. chromogenes
|
48
|
19 (39.6)
| | | |
20.8
|
39.6
|
37.5
|
2.1
| | | | | | | |
S. epidermidis
|
78
|
27 (34.6)
| | | |
38.5
|
26.9
|
15.4
|
6.4
|
12.8
| | | | | | |
S. haemolyticus
|
37
|
10 (27.0)
| | | |
32.4
|
40.5
|
24.3
|
2.7
| | | | | | | |
S. simulans
|
78
|
15 (19.2)
| | | |
38.5
|
42.3
|
19.2
| | | | | | | | |
Cephalothin
| | | | |
≤0.12
|
0.25
|
0.5
|
1
|
2
|
4
|
≥8
| | | | | |
1.0
b
|
S. chromogenes
|
48
| | |
22.9
|
70.8
|
6.3
| | | | | | | | | | |
S. epidermidis
|
78
| | |
21.8
|
55.1
|
9.0
|
14.1
| | | | | | | | | |
S. haemolyticus
|
37
| | |
10.8
|
67.6
|
21.6
| | | | | | | | | | |
S. simulans
|
78
| | |
6.4
|
56.4
|
37.2
| | | | | | | | | | |
Streptomycin
| | | | | | | | |
≤2
|
4
|
8
|
16
|
32
|
64
|
128
|
≥256
|
16.0
b
|
S. chromogenes
|
48
| | | | | | |
81.3
|
14.6
|
4.2
| | | | | | |
S. epidermidis
|
78
|
17 (21.8)
| | | | | |
71.8
|
2.6
|
2.6
|
1.3
|
2.6
|
5.1
|
6.4
|
7.7
| |
S. haemolyticus
|
37
| | | | | | |
97.3
|
2.7
| | | | | | | |
S. simulans
|
78
|
1 (1.3)
| | | | | |
68.2
|
19.2
|
5.1
|
5.1
| | |
1.3
| | |
Neomycin
| | | | | | | |
≤2
|
2
|
4
|
8
|
16
|
32
|
≥64
| | |
1.0
b
|
S. chromogenes
|
48
| | | | | |
97.9
|
2.1
| | | | | | | | |
S. epidermidis
|
78
| | | | | |
89.7
| |
1.3
|
3.8
|
3.8
|
1.3
| | | | |
S. haemolyticus
|
37
| | | | | |
100.0
| | | | | | | | | |
S. simulans
|
78
| | | | | |
100.0
| | | | | | | | | |
Gentamicin
| | | | | |
≤0.25
|
0.5
|
1
|
2
|
4
|
8
|
≥16
| | | | |
0.5
|
S. chromogenes
|
48
| | | |
95.8
|
4.2
| | | | | | | | | | |
S. epidermidis
|
78
| | | |
100.0
| | | | | | | | | | | |
S. haemolyticus
|
37
| | | |
100.0
| | | | | | | | | | | |
S. simulans
|
78
|
2 (2.6)
| | |
88.5
|
9.0
|
2.6
| | | | | | | | | |
Clindamycin
| | | | | | | |
≤1
|
2
|
4
|
≥8
| | | | | |
0.25
|
S. chromogenes
|
48
| | | | | |
100.0
| | | | | | | | | |
S. epidermidis
|
78
| | | | | |
100.0
| | | | | | | | | |
S. haemolyticus
|
37
| | | | | |
97.3
| |
2.7
| | | | | | | |
S. simulans
|
78
| | | | | |
100.0
| | | | | | | | | |
Erythromycin
| | | | | | |
≤0.5
|
1
|
2
|
4
|
≥8
| | | | | |
1.0
|
S. chromogenes
|
48
|
2 (4.2)
| | | |
95.8
| | | |
4.2
| | | | | | |
S. epidermidis
|
78
|
11 (14.1)
| | | |
84.6
|
1.3
| | |
14.1
| | | | | | |
S. haemolyticus
|
37
|
1 (2.7)
| | | |
94.6
|
2.7
| | |
2.7
| | | | | | |
S. simulans
|
78
| | | | |
100.0
| | | | | | | | | | |
Chloramphenicol
| | | | | | | | |
≤2
|
4
|
8
|
16
|
≥32
| | | |
16.0
|
S. chromogenes
|
48
| | | | | | |
4.2
|
77.1
|
18.8
| | | | | | |
S. epidermidis
|
78
|
2 (2.6)
| | | | | |
1.3
|
87.2
|
1.3
|
7.7
|
2.6
| | | | |
S. haemolyticus
|
37
| | | | | | |
10.8
|
86.5
|
2.7
| | | | | | |
S. simulans
|
78
| | | | | | |
3.8
|
47.4
|
46.2
|
2.6
| | | | | |
Tetracycline
| | | | | | |
≤0.5
|
1
|
2
|
4
|
8
|
16
|
32
|
64
|
≥128
| |
1.0
|
S. chromogenes
|
48
|
3 (6.2)
| | | |
87.5
|
6.3
| | | | | |
2.1
|
4.2
| | |
S. epidermidis
|
78
|
36 (46.2)
| | | |
47.4
|
6.4
|
7.7
|
20.5
|
2.6
| |
1.3
|
3.8
|
10.3
| | |
S. haemolyticus
|
37
| | | | |
75.7
|
24.3
| | | | | | | | | |
S. simulans
|
78
|
4 (5.1)
| | | |
21.8
|
73.1
|
2.6
|
1.3
| | | |
1.3
| | | |
Trimetoprim-sulfamethoxazole
| | | | | |
≤0.25/4.25
|
0.5/9.5
|
1/19
|
2/38
|
4/76
|
8/152
|
≥16/304
| | | | |
0.5/9.5
|
S. chromogenes
|
48
|
5 (10.4)
| | |
75.0
|
14.6
|
4.2
| |
2.1
|
2.1
|
2.1
| | | | | |
S. epidermidis
|
78
|
7 (9.0)
| | |
73.1
|
17.9
| |
5.1
|
2.6
| |
1.3
| | | | | |
S. haemolyticus
|
37
| | | |
89.2
|
10.8
| | | | | | | | | | |
S. simulans
|
78
|
6 (7.7)
| | |
29.5
|
62.8
|
6.1
|
2.6
| | | | | | | | |
Vancomycin
| | | | | | | |
≤1
|
2
|
4
|
8
|
16
|
32
|
≥64
| | |
4.0
|
S. chromogenes
|
48
| | | | | |
83.3
|
16.7
| | | | | | | | |
S. epidermidis
|
78
| | | | | |
26.9
|
73.1
| | | | | | | | |
S. haemolyticus
|
37
| | | | | |
81.1
|
18.9
| | | | | | | | |
S. simulans
|
78
|
1 (1.3)
| | | | |
91.0
|
6.4
|
1.3
| | |
1.3
| | | | |
Virginiamycin
| | | | | | |
≤0.5
|
1
|
2
|
4
|
≥8
| | | | | |
1.0
c
|
S. chromogenes
|
48
|
2 (4.2)
| | | |
25.0
|
70.8
|
4.2
| | | | | | | | |
S. epidermidis
|
78
|
1 (1.3)
| | | |
65.4
|
33.3
|
1.3
| | | | | | | | |
S. haemolyticus
|
37
|
1 (2.7)
| | | |
37.8
|
59.5
|
2.7
| | | | | | | | |
S. simulans
|
78
|
2 (2.6)
| | | |
15.4
|
82.1
|
1.3
|
1.3
| | | | | | | |
Avilamycin
| | | | | | |
≤0.5
|
1
|
2
|
4
|
8
|
16
|
32
|
≥64
| | |
ND
|
S. chromogenes
|
48
| | | | | | |
27.1
|
54.2
|
18.8
| | | | | | |
S. epidermidis
|
78
| | | | | | | |
29.5
|
65.4
|
5.1
| | | | | |
S. haemolyticus
|
37
| | | | | | |
16.2
|
59.5
|
21.6
|
2.7
| | | | | |
S. simulans
|
78
| | | | | |
1.3
|
1.3
|
11.5
|
37.2
|
33.3
|
15.4
| | | | |
- In this dataset, all quarters of cows were sampled in a mastitis survey [2]
-
ND not determined
-
aCurrent (March 2015) EUCAST epidemiological cut-off (ECOFF) values (mg/l) for CNS were used to define resistant isolates. If ECOFF for CNS was not available, the value for S. aureus was used. For virginiamycin, ECOFF for S. intermedius was used
-
bECOFF for S. aureus
-
cECOFF for S. intermedius