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Table 2 Somatic mutations in the D-loop sequence in normal tissue, blood and tumour tissue in cases of canine mast cell tumours

From: Identification of additional mitochondrial DNA mutations in canine mast cell tumours

Dog number

Sequences in normal tissue

Sequences in blood

Sequences in tumour tissue

HVI haplotype (normal tissue → tumour tissue)

1

m.15815C

m.15815C/T

m.15815C/T

B1 → B1/B37

2

m.15800T

m.15800T

m.15800C

A18 → B37

m.15912C

m.15912C

m.15912T

 

m.15955C

m.15955C

m.15955T

 

m.16003A

m.16003A

m.16003G

 

3

m.15912C

m.15912C

m.15912T/C

A26 → A101*/102*

m.16003A

m.16003A

m.16003G

 

m.16025C

m.16025C

m.16025T/C

 

4

m.15800 T

m.15800 T

m.15800 C

B11* → A172*

5

m.15800C

m.15800T

m.15800T

B1 → A17

m.15815C

m.15815T

m.15815T

 

m.15912T

m.15912C

m.15912C

 

m.16003G

m.16003A

m.16003A

 

6

m.15795C

m.15795C

m.15795T

A17 → A173*

7

m.16003G

m.16003G

m.16003A

B1 → B12*

13

m.16003A

m.16003A

m.16003G

A19 → A191*

  1. Somatic mutations in the D-loop sequence were present in 8 out of 17 dogs
  2. * Recently reported haplotypes [1618]