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Table 4 Scoring of histopathological changes in Aleutian mink disease virus (AMDV) inoculated mink

From: Progression of experimental chronic Aleutian mink disease virus infection

Tissue

Score/lesion

Sentinel

Post inoculation week

2

4

8

16

24

Lung

Suspect

Mild

2

2/9

2/10

Moderate

1

2/10

Massive

1

2

2/9

Total

2/4 (50 %)

0/4

4/8 (50 %)

4/9 (44 %)

4/10 (40 %)

0/10

Liver

Suspect

1/9

3/9

1/9

Mild

2

2

2/9

4/9

3/9

Moderate

3

2

2

5/9

1/9

3/9

Massive

1

4

1/9

Total

4/4 (100 %)

4/4 (100 %)

8/8 (100 %)

9/9 (100 %)

8/9 (89 %)

7/9 (78 %)

Intestine

Suspect

Mild

1/10

Moderate

1

3/7

Massive

Total

1/4 (25 %)

0/4

0/7

3/7 (43 %)

0/10

1/10 (10 %)

Kidney

Suspect

1/9

3/10

2/10

Mild

1

2

2/9

1/10

2/10

Moderate

2

2/9

1/10

2/10

Massive

3

2

1/9

3/10

Total

4/4 (100 %)

0/4

6/8 (75 %)

6/9 (67 %)

8/10 (80 %)

6/10 (60 %)

Brain

Suspect

1/9

Mild

2

1

5

6/9

3/10

6/10

Moderate

2/10

Massive

Total

2/4 (50 %)

1/4 (25 %)

5/8 (63 %)

7/9 (78 %)

5/10 (50 %)

6/10 (60 %)

Spleen

LF acta

5/8

2/9

4/10

LF depb

3/4

3/4

1/8

2/10

2/10

Dif. depc

2/4

1/8

1/9

2/10

3/10

Stasis

1/4

2/4

2/8

2/9

2/10

1/10

Totald

4/4 (100 %)

4/4 (100 %)

8/8 (100 %)

3/9 (33 %)

8/10 (80 %)

4/10 (40 %)

Mesenteric lymph node

LF dep

3/4

3/4

4/7

4/9

1/9

1/9

Plasma cellse

2/4

3/4

3/7

3/9

3/9

7/9

Macropf

2/4

1/4

3/7

3/9

3/9

Totalg

4/4 (100 %)

3/4 (75 %)

7/7 (100 %)

6/9 (67 %)

5/10 (50 %)

7/9 (78 %)

  1. No. of animals with lesion/no. of tissues examined
  2. In lung, liver, intestine, kidney and brain the grade of the lesions/infiltrations of mononuclear cells were scored semi quantitatively as follows; Suspect: single small lesion. Mild, moderate and massive, respectively: small, moderate, massive lesion/infiltration of mononuclear cells
  3. aActivation of lymphoid follicles (LF act) with presence of necrotic cells and macrophages
  4. bDepletion of lymphoid cells in LF (LF dep)
  5. cDiffuse depletion of lymphoid cells (Dif dep)
  6. dTotal number of mink with histological changes in the spleen
  7. eReduced density of lymphocytes and increased numbers of plasma cells in the sinuses (plasma cells)
  8. fIncreased numbers of macrophages, mainly in the medulla (macrop)
  9. gTotal number of mink with histopathological changes in the mesenteric lymph node