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Table 2 Summary of the effects of propofol and remifentanil on cerebral blood flow and cerebral autoregulation in selected animal species used in experimental neuroscience

From: Effect of propofol and remifentanil on cerebral perfusion and oxygenation in pigs: a systematic review

Species

CBF

CA

References

P

R

PR

P

PR

Humans

↓

↑↓*

↓

Preserved

Preserved

[18, 52, 55, 56, 58]

Dog

↓

↓

•

Preserved

•

[96, 97]

Rabbit

↓

•

•

•

•

[98]

Rat

↓

•

•

Preserved

•

[99]

  1. CBF: cerebral blood flow; CA: cerebral autoregulation; P: propofol; R: remifentanil; PR: propofol-remifentanil combination; ↑: increased; ↓: decreased; •: uncertain; *: dose dependant