Table 4 Effects of colistin compared to alternative measures for control of post weaning diarrhoea (PWD) in pigs
From: Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies
Trials | ADG (g/day) | Ileum villus height (μm) | Ileum crypt depth (μm) | E. coli (log 10 CFU/g) | Diarrhea | References |
|---|---|---|---|---|---|---|
Study 1: HP | d0–35 | d35 | d35 |  | d0–21c | [151] |
 Hop β-acidse (360 mg/kg) | 441a | 337 | 214 | NA | 1.51 | |
 Colistin sulfate (40 mg/kg) | 425a | 366 | 230 | NA | 1.51 | |
 Control | 387b | 349 | 219 | NA | 1.72 | |
Study 2: HP | d21 | d21 | d21 | d21 | Â | [152] |
 Two Macrocephala flavored powder (3000 mg/kg) | NA | 121 | 66.30 | 7.93a | NA | |
 Colistin sulfate (300 mg/kg) | NA | 107 | 57.63 | 6.48a | NA | |
 Control | NA | 120.49 | 64.75 | 6.63 | NA | |
Study 3: HP | d1–21 | d21 | d21 | Ileum d21f | d1–7c | [79] |
 Recombinant plectasin (Ple) (60 mg/kg) | 311.43a | 227.69 | 95.53 | 6.61 | 10.48 | |
 Colistin sulfate (60 mg/kg) | 333.57a | 195.57 | 88.48 | 5.86 | 8.57 | |
 Control | 193.10b | 160.45 | 105.82 | 6.29 | 36.19 | |
Study 4: HP | d0–14 |  |  |  | d0–14 | [81] |
 Medium-chain triglyceride (MCT) (3000 mg/kg) | 141.2 | NA | NA | NA | 0.91 | |
 Colistin sulfate (40 mg/kg) | 142.2 | NA | NA | NA | 0.91 | |
 Control | 130.7 | NA | NA | NA | 1.01 | |
Study 5: HP | d28–56 | d42 | d42 |  | d28–56d | [157] |
 Freshwater microalgae Chlorella vulgaris (1000 mg/kg) | 395 | 435 | 278 | NA | 24b | |
 Colistin sulfate (20 mg/kg) | 400 | 440 | 283 | NA | 34a | |
 Control | 393 | 415 | 299 | NA | 36a | |
Study 6: CP | Â | d1 post challengee | d1 post challengee | Â | Â | [158] |
 Live yeast (5 × 1010 CFU/kg) | NA | 322 | 246 | NA | NA | |
 Colistin sulfate (1000 mg/kg) | NA | 334 | 236 | NA | NA | |
 Control | NA | 294 | 199 | NA | NA |