Fig. 2

Brain magnetic resonance imaging (MRI) of Shih Tzu dogs with lissencephaly. Transverse T1-weighted (a, e), T2-weighted (b, f), dorsal 3D HYCE (c), fluid-attenuated inversion recovery (FLAIR) (g), and mid-sagittal T1-weighted (d, h) in the third and fourth cases. MRI of the third dog showed a few sulci in the temporal lobe, including the caudal sylvian gyri and lateral rhinal sulci (arrow). The main gyri (including the marginal, ectomarginal and suprasylvian) and the suprasylvian sulcus were absent. The internal capsule was abnormally small, and internal hydrocephalus was visualized (a–d). MRI of the fourth dog showed generalized agyria with an absence of sulci and thickened gray matter with smooth appearance (arrow) (e, f). Rhinal sulci in the temporal lobe were not apparent and cingulate gyrus was absent (arrowhead). Internal hydrocephalus and supracollicular fluid accumulation associated with dorsocaudal outpocketing of the third ventricle (type SFA-III) were observed (g, h)