Fig. 2
From: Exposure to benzylpenicillin after different dosage regimens in growing pigs
Total plasma concentration–time courses of benzylpenicillin in pigs after repeated intramuscular dosing of different formulations. Total plasma concentration–time courses of benzylpenicillin after repeated intramuscular dosing of different formulations of the drug in pigs experimentally inoculated with Actinobacillus pleuropneumoniae serotype 2. Each line represents an individual pig. Plot a 20 mg/kg Ethacilin qd to six pigs for 3 days. Plot b 20 mg/kg Ethacilin bid to six pigs for 3 days. Plot c 30 mg/kg Ethacillin qd to six pigs for 3 days. Plot d 30 mg/kg Ultrapen qd to six pigs for 3 days. The horizontal lines denote the approximate total plasma concentration of benzylpenicillin necessary to exceed MIC of 500 µg/L for A. pleuropneumoniae, considering a protein binding of 45%