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Table 1 Summary of clinical and pathological findings

From: Reproduction of contagious bovine pleuropneumonia via aerosol-based challenge with Mycoplasma mycoides subsp. mycoides

Heifer number Clinical signs Macroscopic findings Histopathological findings
1 (†54 dpi) None None None
2 (†25 dpi) Cough, fever Fibrous adhesion: At right diaphragmatic lobe Necrotizing and suppurative broncho-interstitial pneumonia, entire lobuli affected, extension of necrosis to adjacent lobuli, oedema, fibrin exudation and suppurative inflammation in interlobular septae, fibrin thrombi in interlobular lymphatics, beginning fibrosis at margins of lesions
Sequester: Seven (1–2 cm in diameter) in right and left diaphragmatic lobe
3 (†53 dpi) None Fibrous adhesion: Between left middle and caudal lobe
Between caudal lobe and parietal pleura
Necrotizing and suppurative broncho-interstitial pneumonia, entire lobuli affected, thick, cell rich fibrous connective tissue capsule formation in interlobular septae with lymphocytic infiltration
Sequester: Two (0.5 and 5 cm in diameter) in left middle and caudal lobe
One (3 cm in diameter) in right diaphragmatic lobe
4 (†54 dpi) Cough Fibrous adhesion: Between left caudal lobe and parietal pleura Necrotizing and suppurative broncho-interstitial pneumonia, entire lobuli affected
Sequester: One (3 cm in diameter) in left caudal lobe Thick, cell rich fibrous connective tissue capsule formation in interlobular septae with lymphocytic infiltration
5 (†55 dpi) Cough Fibrous adhesion: At right caudal lobe None
6 (†55 dpi) Cough, fever Fibrous adhesion: Multiple at all lung lobes Necrotizing and suppurative broncho-interstitial pneumonia, entire lobuli affected
Sequester: Seven (3–12 cm in diameter) in all lung lobes Thick, cell rich fibrous connective tissue capsule formation in interlobular septae with lymphocytic infiltration
  1. Day of euthanasia; dpi: days post infection