Fig. 3

Histological sections of skin wounds biopsies after 7 days of treatment. a, b, and c Photomicrographs showing control wound; d, e, and f Photomicrographs showing wound treated with allogeneic adipose–derived mesenchymal stem cells. a Epidermal hyperplasia (EH) and full thickness fibroplasias (F) in dermis, bar: 400 µm. b Mononuclear inflammatory cell infiltrate (MII) extending mainly through the superficial and medium dermis, bar: 200 µm. c Orthokeratotic (O) and parakeratotic (P) hyperkeratosis, intracellular edema (IE), hypergranulosis (HG), and acanthosis (A), bar: 100 µm. The wound skin edge in control wound shows changes compatible with chronic dermatitis without follicular components. d and e Thin epidermis without evidence of inflammation; moreover multiple hair follicles (HF) can be observed, bar: 400 µm (d) and 200 µm (e). f Orthokeratosis (O), bar: 100 µm. Treated wound shows histological features compatible with the process of skin regeneration. a–f Hematoxylin and eosin staining