Study | Bianco et al. [28] | Balog et al. [18] | Huang et al. [29] | Putsche and Kohn [8] | Kohn et al. [10] | Yau and Bianco [17] |
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Characteristics | Randomized, double-blinded, placebo-controlled, clinical trial | (Randomized), multicenter, blinded, clinical trial | Retrospective (case–control study) | Retrospective case series with a nested cohort study | Prospective case series | Prospective case series |
Critical appraisal | LOE 1++ Very small number of dogs in each group Strongly supportive enrollment Low statistical power and risk of confounding | LOE 1+ Small number of dogs in each group Uncertain enrollment Low statistical power and risk of confounding | LOE 3 Small to very small number of dogs in each group Uncertain enrollment | LOE 3 Small to very small number of dogs in each group Uncertain enrollment | LOE 3 Very small number of dogs in each group Uncertain enrollment | LOE 3 Very small number of dogs in each group Uncertain enrollment |
Results of individual sources | Tx1: CS + hIVIG C: CS Improvementa(Tx1): Platelet recovery Duration of hospitalization No improvementb: Complete platelet recovery Survival 6-month | Tx1: CS + hIVIG C: CS + Vinc No improvementb: Platelet recovery Duration of hospitalization Survival to discharge Survival 6-month Survival 1-year | N/A | Tx1: CS Tx2: CS + Vinc Tx3: CS + Aza Tx4: CS + Cyclo C: Tx2 + Tx3 + Tx4 No improvementb: Mortality 1684-days Relapse 1684-days | N/A | N/A |