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A Study on the Effects of Inhibition of Prostaglandin Biosynthesis with Flunixin Meglumine and Later Administration of Prostaglandin F2α on the Intraluminal Pressure Variations in the Isthmus of the Oviduct in Unrestrained Gilts

Acta Veterinaria Scandinavica volume 34, pages 125–131 (1993)Cite this article

Abstract

Three gilts were each equipped with 2 ultra-miniature pressure sensors, placed at 2 different points along the same isthmus of the oviduct. Following base recordings of isthmic intraluminal pressure, the gilts were treated with 2.2 mg flunixin meglumine (FM) per kg body weight. After FM treatment, the peripheral plasma levels of 15-ketodihydro-PGF2α, the major metabolite of prostaglandin F2α (PGF2α), decreased within 30 min. The frequency of the phasic pressure fluctuations in the isthmus of the oviduct decreased after FM treatment. Exogenous administration of PGF2α increased the peripheral plasma levels of 15-keto- dihydro-PGF2α. When administered at a dose of 0.1 mg, PGF2α produced an increase in the frequency of the phasic pressure fluctuations in the oviductal isthmus. When the PGF2α dose was increased to 0.5 mg, a marked increase in the base and total pressures was seen in addition to the increase in the frequency of the phasic pressure fluctuations.

References

  • Boilert B, Edqvist L-E, Johansson EDB, Lindberg P, Martinsson K: The influence of conjugated estrogens in radioimmunoassays using different antibodies against estradiol-17ß. Steriods. 1973, 22, (891–894).

    Article  CAS  Google Scholar 

  • Bosú WTK, Edqvist L-E, Lindberg P, Martinsson K, Johansson EDB: The effect of various dosages of lynesterol on the plasma levels of oestrogens and progesterone during the menstrual cycle in the rhesus monkey. Contraception. 1976, 13, (677–684).

    Article  Google Scholar 

  • Granström E, Kindahi H: Radioimmunoassay of the major plasma metabolite of PGF2a, 15-keto-13, 14-dihydro-PGF2a. Meth. Enzymol. 1982, 86, (320–339).

    Article  Google Scholar 

  • Henriksson A, Gustavsson A, Einarsson S: A new method for continuous recording of oviductal pressure variations in unrestrained gilts. Acta physiol, scand. 1987, 131, (303–307).

    Article  CAS  Google Scholar 

  • Kunavongkrit A, Kindahi H, Madej A: Clinical and endocrinological studies in primiparous zero-weaned sows: 2. Hormonal patterns of normal cycling sows after zero-weaning. Zbl. Vet. Med. A. 1983, 30, (616–624).

    Article  CAS  Google Scholar 

  • Odensvik K, Cort N, Basu S, Kindahi H: Effect of flunixin meglumine on prostaglandin F2a synthesis and metabolism in the pig. J. vet. Pharmacol. Therap. 1989, 12, (307–311).

    Article  CAS  Google Scholar 

  • Pettersson A: Cyclic variations in intraluminal pressure in the isthmus of the oviduct in unrestrained gilts. J. vet. Med. A. 1991, 38, (337–343).

    Article  CAS  Google Scholar 

  • Rodriguez-Martinez H, Einarsson S: Influence of prostaglandins on the spontaneous motility of the pig oviducts. Anim. Reprod. Sei. 1985, 8, (259–279).

    Article  CAS  Google Scholar 

  • Rodriguez-Martinez H, Einarsson S, Larsson B, Akusu M, Settergren I: Spontaneous motility of the pig oviduct in vitro. Biol. Reprod. 1982a, 26, (98–104).

    Article  CAS  Google Scholar 

  • Rodriguez-Martinez H, Einarsson S, Larsson B: Spontaneous motility of the pig oviduct in the anaesthetized pig. J. Reprod. Fert. 1982b, 66, (615–624).

    Article  CAS  Google Scholar 

  • Rodriguez-Martinez H, Garcia B, Ohanian C, Einarsson S: Histochemical investigation on the distribution of adrenergic nerve terminals in the porcine oviduct. Zbl. Vet. Med. A 1982c, 29, (64–71).

    Article  CAS  Google Scholar 

  • Rodriguez H, Kunavongkrit A: Chronical venous catheterization for frequent blood sampling in unrestrained pigs. Acta vet. scand. 1983, 24, (318–320).

    Article  CAS  Google Scholar 

  • Rodriguez-Martinez H, Petroni A, Einarsson S, Kin-dahl H: Concentrations of prostaglandin F2a in the pig oviductal fluid. Prostaglandins. 1983, 25, (413–424).

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This study has been supported by the Swedish Council for Forestry and Agricultural Research. Special thanks to Marie Sundberg and Birgitta Berner for secretarial help and to the Department of Clinical Chemistry for performing the steroid analysis.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, P.O. Box 7039, S-750 07, Uppsala, Sweden

    A. Pettersson, S. Einarsson & H. Kindahl

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  1. A. Pettersson
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  2. S. Einarsson
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  3. H. Kindahl
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Pettersson, A., Einarsson, S. & Kindahl, H. A Study on the Effects of Inhibition of Prostaglandin Biosynthesis with Flunixin Meglumine and Later Administration of Prostaglandin F2α on the Intraluminal Pressure Variations in the Isthmus of the Oviduct in Unrestrained Gilts. Acta Vet Scand 34, 125–131 (1993). https://doi.org/10.1186/BF03548200

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Acta Veterinaria Scandinavica

ISSN: 1751-0147