The costs of interdigital phlegmon in four loose-housed Finnish dairy herds
© Häggman et al. 2015
Received: 8 October 2015
Accepted: 14 December 2015
Published: 30 December 2015
The aim of the study was to provide detailed herd level cost information about an outbreak of interdigital phlegmon (IP), which has been an emerging problem with enlarged loose house barns in Finland in recent years. During enlargement, the farmer’s financial situation is sensitive because of the large investments to the farm business and unexpected costs can risk the farm’s survival.
The University of Helsinki research herd and three commercial herds having outbreaks of IP in 2012 or 2013 were visited to collect detailed information about the costs and economic impact of the outbreaks. The majority of the costs came from the discarded milk due to the antibiotic treatments. In Finland IP is usually treated with parental benzylpenicillin for 5 days which result in discarded milk for a total of 11 days. Third generation cephalosporins, widely used in other countries, have no milk withdrawal time. However, the use of these antibiotics is not recommended in Finland since these antimicrobials are critically important for human health. Herd-level costs varied between 4560 and 28,386 € depending on the herd size, the frequency of the infected cows, the antibiotics used and other costs involved. The average cost per infected cow was 489 €.
The outbreaks of IP cause severe economic losses to dairy farms and the costs are lower if cows are treated with antibiotics with no withdrawal time. However, other costs, such as involuntary culling, reduced production and fertility also produce substantial costs to the farms. Early detection of sick animals, rapid treatment and control measures to limit the outbreak of IP can lower the costs. Because of the high costs farms should concentrate on preventing the disease.
Interdigital phlegmon (IP) or foot rot is a necrotizing soft tissue inflammation in the interdigital region of the foot [1–3]. IP is believed to be a mixed infection of multiple anaerobic pathogens, such as Fusobacterium necrophorum (which is believed to be the primary pathogen), Dichelobacter nodus, Porphyromonas levii, P. asaccharolytica, Prevotella intermedia, and P. melaninogenica [3, 4]. However, the exact pathogenic mechanisms of these bacteria are still not determined. F. necrophorum is commonly found in the soil and can be isolated on the feet, rumen and feces of healthy cows , hence injury to the skin of the interdigital area can predispose the cow to IP . In recent years, outbreaks of IP have occurred in Finnish dairy farms. IP is painful, causes lameness, and is also a costly disease, which can have a serious impact on the farm profitability. Specifically, the effect of the disease is dramatic if the majority of the cows in a herd are infected.
In Finland IP is usually treated with parenteral benzylpenicillin for 5 days (20 mg/kg) with a milk withdrawal time of 6 days, which results in discarded milk of a total of 11 days. Additionally, cows are usually treated with non-steroidal anti-inflammatory drugs and in some cases foot baths for the healthy cows are recommended for controlling the infection in the herd. If IP is diagnosed and treated early the antibiotic treatment is usually successful and most cases respond rapidly , whereas the response to delayed antibiotic treatment can fail to control the infection and in the worst case the cow has to be culled . Permanent working group on the antimicrobials of the Ministry of Agriculture and Forestry in Finland has set guidelines for antimicrobial treatments of common diseases in animals. The primary antimicrobial recommendation for IP is use of narrow-spectrum antibiotic benzylpenicillin and the secondary use of oxytetracycline or macrolides . Ceftiofur, a third generation cephalosporin, does not have a milk withdrawal time and is available in Finland. However, as it belongs to the group of antimicrobials, which is identified by the World Health Organization (WHO) as critically important for human health, the use of this antimicrobial is not recommended since its impact to antimicrobial resistance . According to the one health perspective, Nordic countries have managed to keep the prevalence of antibiotic resistant at a low level which is important to maintain the effectiveness of these antibiotics also in the future. If the effectiveness of these antibiotics is lost there will be a need to develop a new medicine which is turned out to be challenging.
The aim of this study was to provide detailed cost information about an outbreak of IP at the herd level. Such information is not possible to obtain from the standard Finland health or economic recording and no previous studies have been undertaken to compile the economic costs associated with an IP outbreak.
Other costs, such as the increased use of copper sulfate in the foot baths, were also included. IP can also lower the milk production, prolong the calving interval and predispose cows to other diseases . A decrease in milk production was not noted in this study. The information about the cost of the prolonged calving interval was not available and was not included in this study. However, an average dairy cow with a clinical foot disorder has a prolonged calving interval of 12 days  and in Finland the daily cost for each open day is about 2.5 € .
Farm location, number of cows, number of cows treated and antimicrobials used
Cows total (n)
Infected cows (n)
Antimicrobials used during IP outbreak
A, Southern Finland
71 treatments: benzylpenicillina (300,000 IU/ml)
1 treatment: oxytetracyclineb (100 mg/ml)
B, Central Finland
4 treatments: oxytetracyclineb (100 mg/ml)
6 treatments: benzylpenicillinc (300 mg/ml)
C, Northern Ostrobothnia
22 treatments: benzylpenicillin natriumd (24 g)
18 treatments: benzylpenicillinc (300 mg/ml)
4 treatments: benzylpenicillina (300,000 IU/ml)
11 treatments: ceftiofure (50 mg/ml)
D, Central Finland
6 treatments: oxytetracyclineb (100 mg/ml)
32 treatments: benzylpenicillinc (300 mg/ml)
37 treatments ceftiofure (50 mg/ml)
The percentage of infected cows, herd-level costs (€) and costs divided with the number of infected cows
Infected cows (%)
Cost due to discarded milk
Extra labor cost
Extra claw trimming cost
Costs due to culling
Total cost/infected cow
The costs varied between the farms (Table 2), herd-level costs being the highest in the University research farm (A), where the costs due to the discarded milk were high when the majority of the cows were infected, milk production was high and cows were treated with regular antibiotics. In two study herds (C and D), however, cows were treated with ceftiofur (Table 1) and milk losses were not severe as some veterinarians use it despite the recommendations. The average cost per infected cow was 489 €, the lowest costs in farm D where the majority of the cows were infected and half of them were treated with ceftiofur. In farm B only a small number of cows were infected and the total costs were low which could be due to the early detection of the disease and the fact that affected cows were isolated from the rest of the herd during the early infectious stages. All the cows in farm B were monitored carefully and closely inspected if something abnormal was observed. In farm C, seven calves were lost and four cows had to be culled producing extra costs.
IP epidemics cause economic losses to dairy industry and the majority of the costs come from the discarded milk due to the treatments with antibiotics. Also, other costs involved (involuntary culling, reduced production and fertility) are substantial. However, rapid treatment and control measures to limit the outbreak of IP will greatly reduce the total herd cost. Based on this study the average cost per infected cow can be assumed to be 600–700 € when the cow is treated with benzylpenicillin. Because of high costs of IP it would be more efficient on the economic point of view to focus on the prevention of the disease.
JH collected and analysed the data, performed the literature review and drafted the manuscript. RJ performed the farm visits and hoof inspections in the commercial farms, established contact with the farms included in the study and commented on the manuscript. HS took part in the literature review and writing. JJ participated in the planning of the study and commented on the manuscript. TS participated in planning the study and commented on the manuscript. All authors read and approved the final script of manuscript.
The authors thank the owners of the commercial dairy farms B, C and D for their participation in the study and the staff of the University of Helsinki research farm for their help in collection of the data. This study was funded by the Ministry of Agriculture and Forestry project (2066/312/2011) for infectious hoof diseases in new loose house stalls in Finland and the future development fund of the University of Helsinki.
The authors declare that they have no competing interests.
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- Greenough PR. Bovine laminitis and lameness: a hands on approach. 3rd ed. Edinburgh: Saunders Elsevier; 2007.Google Scholar
- Langworth BF. Fusobacterium necrophorum: its characteristics and roles as an animal pathogen. Bacteriol Rev. 1977;41:373–90.PubMedPubMed CentralGoogle Scholar
- Nagaraja TG, Narayanan SK, Stewart GC, Chengappa MM. Fusobacterium necrophorum infections in animals: pathogenesis and pathogenic mechanisms. Anaerobe. 2005;11:239–46.PubMedView ArticleGoogle Scholar
- Sweeney M, Watts H, Portis E, Lucas M, Nutsch R, Meeuwse D, Bade D, Oliver V, Morck DW, Shinabarger D, Poppe S, Peterson M, Sweeney D, Knechtel M, Zurenko G. Identification of Porphyromonas levii isolated from clinical cases of bovine interdigital necrobacillosis by 16S rRNA sequencing. Vet Ther. 2009;10:1–10.Google Scholar
- Gröhn H. Interdigital Phlegmon the disease of an expanding dairy farm [in Finnish]. Savonia University of Applied Sciences. 2010. http://www.theseus.fi/handle/10024/22678. Accessed 6 Oct 2015.
- Finnish Food Safety Authority Evira. Recommendations for the use of antimicrobials against the most common infectious diseases of animals [in Finnish and Swedish]. http://www.evira.fi/portal/fi/tietoa+evirasta/julkaisut/?a=view&productId=135 (2009). Accessed 6 October 2015.
- World Health Organization (WHO). Critically important antimicrobials for human medicine, 3rd ed. Switzerland, WHO;2012. p. 10–11.Google Scholar
- LUKE Natural Resources Institute Finland: Economydoctor. https://portal.mtt.fi/portal/page/portal/economydoctor/farm_economy/2013/key_figures_by_production_type (2015). Accessed 6 October 2015.
- Fourichon C, Seegers H, Malher X. Effect of disease on reproduction in the dairy cow: a meta-analysis. Theriogenology. 2000;53:1729–59.PubMedView ArticleGoogle Scholar
- Pedersen J, Sørensen MK, Toivonen M, Eriksson J-Å, Aamand GP. Report on economic basis for a nordic total merit index. 2008. http://www.nordicebv.info/wp-content/uploads/2015/05/Report-on-Economic-Basis-for-a-Nordic-Total-Merit-Index.pdf. Accessed 6 October 2015.